{"id":"W4317493828","doi":"10.1111/bcp.15666","title":"Metabolomic identification of predictive and early biomarkers of cisplatin‐induced acute kidney injury in adult head and neck cancer patients","year":2023,"lang":"en","type":"article","venue":"British Journal of Clinical Pharmacology","topic":"Chemotherapy-induced organ toxicity mitigation","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Hospital for Sick Children; Western University","funders":"Canadian Institutes of Health Research; Western University","keywords":"Hippuric acid; Cisplatin; Creatinine; Medicine; Acute kidney injury; Urinary system; Urine; Urology; Metabolomics; Renal function; Internal medicine; Pharmacology; Gastroenterology; Chemotherapy; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009683667,0.0001007183,0.0007187575,0.0002596169,0.00002306578,0.000007641926,0.0000842854,0.0001967543,0.00003483739],"category_scores_gemma":[0.001005282,0.0001119864,0.0001023574,0.0003571962,0.0002247233,0.0001815619,0.0000407277,0.0004395421,7.685223e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003891592,"about_ca_system_score_gemma":0.0002368829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001428421,"about_ca_topic_score_gemma":0.000008782008,"domain_scores_codex":[0.9973845,0.0002468621,0.001756631,0.0002044974,0.0002505186,0.0001569344],"domain_scores_gemma":[0.997719,0.0002410233,0.001226169,0.00006137676,0.0005309126,0.0002214805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00287156,0.0004029709,0.3557,0.0001000032,0.0006528755,0.00004481114,0.0002626032,9.128593e-7,0.6002119,8.036263e-7,0.00257328,0.0371783],"study_design_scores_gemma":[0.009429174,0.001002433,0.8204386,0.0003224351,0.0003460437,0.00005328568,0.00002181521,0.0002167485,0.1680365,0.00005431481,0.00001647902,0.0000621419],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976547,0.0001275782,0.000006229722,0.0009904348,0.0007006562,0.0003692553,0.000131974,0.000008380101,0.0000107521],"genre_scores_gemma":[0.9945906,0.004608764,0.0001089338,0.0004670787,0.0001745201,0.000006287606,0.00001141135,0.0000184646,0.00001392108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4647386,"threshold_uncertainty_score":0.4566674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02761704334101359,"score_gpt":0.3980516095193778,"score_spread":0.3704345661783642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}