{"id":"W4317497423","doi":"10.1126/science.abj7412","title":"<i>BTG1</i> mutation yields supercompetitive B cells primed for malignant transformation","year":2023,"lang":"en","type":"article","venue":"Science","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Cancer Institute; Deutsche Krebshilfe; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Agency for Science, Technology and Research; Damon Runyon Cancer Research Foundation; National Science Foundation; Incyte; Deutsche Forschungsgemeinschaft; Michael Smith Health Research BC; Memorial Sloan-Kettering Cancer Center; Cancer Research Institute","keywords":"Germinal center; Biology; Multicellular organism; Mutation; Immune system; Acquired immune system; Antibody; Phenotype; Mechanism (biology); Limiting; B cell; Genetics; Gene; Immunology; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004208714,0.00006536461,0.0000509023,0.00007923719,0.0001748554,0.00002855979,0.0001261167,0.00006364548,0.000005438655],"category_scores_gemma":[0.00004501372,0.00006415983,0.00004000239,0.0004122483,0.0001355572,0.00001732418,0.00002048879,0.00003011751,0.00002469863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002930184,"about_ca_system_score_gemma":0.0001536323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006298485,"about_ca_topic_score_gemma":0.000020313,"domain_scores_codex":[0.9992483,0.00001437082,0.0001204019,0.0002437753,0.0001689356,0.000204164],"domain_scores_gemma":[0.9996481,0.00001226173,0.00003301445,0.0001344414,0.0001285182,0.00004368609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001834431,0.000005656381,0.00001353894,0.000009584091,0.000002845309,1.567383e-7,0.0002617844,0.001820043,0.9928593,0.0002318766,0.0002333885,0.004543465],"study_design_scores_gemma":[0.0002614942,0.0001253595,0.001301763,0.00001044461,0.000005890149,0.000003261482,0.0001955797,0.004575684,0.9855229,0.0002261506,0.007678233,0.00009319968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790744,0.00005340538,0.01896553,0.0003683529,0.0004363501,0.0004161139,0.00002744279,0.00003381728,0.0006246353],"genre_scores_gemma":[0.9987294,0.0000515163,0.0005011448,0.0000627959,0.00009319841,0.00004578313,0.0001377027,0.000007546577,0.0003708891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01965507,"threshold_uncertainty_score":0.2616362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01027788311222595,"score_gpt":0.2617757751198803,"score_spread":0.2514978920076543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}