{"id":"W4317497423","doi":"10.1126/science.abj7412","title":"<i>BTG1</i> mutation yields supercompetitive B cells primed for malignant transformation","year":2023,"lang":"en","type":"article","venue":"Science","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Cancer Institute; Deutsche Krebshilfe; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Agency for Science, Technology and Research; Damon Runyon Cancer Research Foundation; National Science Foundation; Incyte; Deutsche Forschungsgemeinschaft; Michael Smith Health Research BC; Memorial Sloan-Kettering Cancer Center; Cancer Research Institute","keywords":"Germinal center; Biology; Multicellular organism; Mutation; Immune system; Acquired immune system; Antibody; Phenotype; Mechanism (biology); Limiting; B cell; Genetics; Gene; Immunology; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001331198,0.0002107922,0.0001658922,0.0003055656,0.0001241597,0.0002989393,0.0001954673,0.0002866714,0.001762482],"category_scores_gemma":[0.0001574193,0.0001163632,0.0001448617,0.0001724439,0.00027622,0.00009717728,0.00023413,0.0004372336,0.0006535283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000281926,"about_ca_system_score_gemma":0.00013111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007195014,"about_ca_topic_score_gemma":0.0007517267,"domain_scores_codex":[0.9998492,0.00002566698,0.00001410206,0.0000324466,0.0000452501,0.0000332754],"domain_scores_gemma":[0.9998001,0.00004715951,0.00005123043,0.00003816924,0.00000903976,0.00005418764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004347456,0.00001386913,0.0001976293,0.000006440763,0.000003004316,0.00004740548,0.00001040966,0.00007692769,0.998746,0.0002534476,0.00004676538,0.0005546109],"study_design_scores_gemma":[0.00001776517,0.0002077424,0.005586229,0.000003874796,0.000009949102,0.0007915997,0.00002693856,0.001387114,0.9880369,0.0002225668,0.003704459,0.00000498972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938065,0.0002980511,0.002103313,0.0001181537,0.00002204644,0.00001977275,0.0003390825,0.0001804292,0.003112647],"genre_scores_gemma":[0.9967828,0.0001477952,0.0008023214,0.00005106126,0.000007004602,0.00001168078,0.0002983257,0.00007467735,0.001824337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001762482,"threshold_uncertainty_score":0.005896091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01027788311222595,"score_gpt":0.2617757751198803,"score_spread":0.2514978920076543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}