{"id":"W4317500685","doi":"10.1038/s41551-022-00998-9","title":"Opportunities and challenges in the diagnostic utility of dermal interstitial fluid","year":2023,"lang":"en","type":"review","venue":"Nature Biomedical Engineering","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":325,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Air Force Office of Scientific Research; Division of Chemical, Bioengineering, Environmental, and Transport Systems; Office of Naval Research; Natural Sciences and Engineering Research Council of Canada; U.S. Air Force; Sandia National Laboratories; National Nuclear Security Administration; U.S. Department of Health and Human Services; National Institutes of Health; National Science Foundation; Division of Electrical, Communications and Cyber Systems; U.S. Department of Energy; U.S. Department of Defense; University of Cincinnati; Medtronic Foundation; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Interstitial fluid; Medicine; Tissue fluid; Immune system; Body fluid; Dermis; Pathology; Intensive care medicine; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001999215,0.0007851495,0.0013297,0.001811975,0.0003771598,0.001954203,0.001078325,0.002432797,0.002423541],"category_scores_gemma":[0.001404733,0.0004704754,0.0008079358,0.00123726,0.001426492,0.002913777,0.001016025,0.003581245,0.001766542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009209658,"about_ca_system_score_gemma":0.001229543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001130773,"about_ca_topic_score_gemma":0.001437265,"domain_scores_codex":[0.9993345,0.0001548574,0.00005615389,0.0001332773,0.0002552386,0.00006597547],"domain_scores_gemma":[0.9988953,0.0006837432,0.00007980056,0.00003445698,0.0002511519,0.00005561725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001207541,0.0001340837,0.0003938646,0.01415422,0.00007705624,0.0005916224,0.0002191967,0.0007976824,0.01052261,0.02820728,0.02761731,0.9171643],"study_design_scores_gemma":[0.00001414075,0.0001889266,0.0005481197,0.001909904,0.00005314212,0.002336518,0.0001901298,0.0004004763,0.003714745,0.007024604,0.983574,0.00004508311],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003019287,0.9960068,0.0007276954,0.0009824042,0.0003392735,0.000005560117,0.00001389488,0.00001059647,0.001611891],"genre_scores_gemma":[0.00322379,0.9934634,0.0009102878,0.0007865123,0.0005375853,0.00001541078,0.00002889142,0.000004452278,0.001029719],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002432797,"threshold_uncertainty_score":0.01057297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3472412409062192,"score_gpt":0.4649250292558288,"score_spread":0.1176837883496096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}