{"id":"W4317506066","doi":"10.3390/metabo13020151","title":"Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity","year":2023,"lang":"en","type":"article","venue":"Metabolites","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; University of British Columbia; Natural Sciences and Engineering Research Council of Canada; Karolinska Institutet; Michael Smith Health Research BC; Science for Life Laboratory; Canada Foundation for Innovation","keywords":"Dihydrofolate reductase; Chemistry; Cancer cell; In silico; Proguanil; Cancer; Metabolite; Pharmacology; Biochemistry; Enzyme; Biology; Gene; Chloroquine; Genetics; Immunology; Malaria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006965177,0.000215816,0.0002905288,0.0001376307,0.0001001836,0.0002963301,0.0002240258,0.0001893908,0.001930377],"category_scores_gemma":[0.0001419509,0.00009736902,0.0002815032,0.0001713863,0.0001086646,0.0002356884,0.0001401741,0.0003810377,0.0002805965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003603375,"about_ca_system_score_gemma":0.0001916817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001582137,"about_ca_topic_score_gemma":0.00283067,"domain_scores_codex":[0.9999495,0.000007721974,0.000002545737,0.00001223608,0.00001837714,0.000009684417],"domain_scores_gemma":[0.9999717,0.000007872896,0.000008877639,0.00000305145,0.000004562353,0.000003988489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005859524,0.000211379,0.001934325,0.001033488,0.00007034986,0.0004743074,0.0000716498,0.02731606,0.9130983,0.002890603,0.001283184,0.05103043],"study_design_scores_gemma":[0.0001422,0.002189059,0.003952345,0.00005988908,0.0001131671,0.0006422002,0.00006541957,0.02939807,0.9234249,0.0006115488,0.0393727,0.00002850484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9467148,0.02101059,0.0117487,0.0003619405,0.00006716549,0.0001439634,0.001716149,0.0004445432,0.01779216],"genre_scores_gemma":[0.9873083,0.005480036,0.004585777,0.00005773909,0.000009096146,0.00002806851,0.000778751,0.00001725972,0.001734996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001930377,"threshold_uncertainty_score":0.006457806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02497574594991467,"score_gpt":0.3147182043274793,"score_spread":0.2897424583775646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}