{"id":"W4317506066","doi":"10.3390/metabo13020151","title":"Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity","year":2023,"lang":"en","type":"article","venue":"Metabolites","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; University of British Columbia; Natural Sciences and Engineering Research Council of Canada; Karolinska Institutet; Michael Smith Health Research BC; Science for Life Laboratory; Canada Foundation for Innovation","keywords":"Dihydrofolate reductase; Chemistry; Cancer cell; In silico; Proguanil; Cancer; Metabolite; Pharmacology; Biochemistry; Enzyme; Biology; Gene; Chloroquine; Genetics; Immunology; Malaria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002019844,0.0002190602,0.0005082982,0.0003750178,0.00006240337,0.00002639489,0.00006592828,0.00006768424,0.0002212058],"category_scores_gemma":[0.0000389291,0.0001727386,0.00006186744,0.0008179374,0.0000369031,0.0000983581,0.00007865922,0.0001210292,0.0001795525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000753162,"about_ca_system_score_gemma":0.0001109745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000748487,"about_ca_topic_score_gemma":0.0003086884,"domain_scores_codex":[0.9986869,0.00004787512,0.0002033738,0.0003931656,0.0002407897,0.0004278908],"domain_scores_gemma":[0.9994739,0.00005839029,0.00004507006,0.0001813864,0.00005363107,0.0001875914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009264833,0.0002367416,0.738149,0.00009577406,0.000253978,0.0001018087,0.001580684,0.00007176906,0.233588,0.00007964979,0.006652806,0.01909713],"study_design_scores_gemma":[0.001027224,0.00002576963,0.707325,0.00007660851,0.00009976886,0.000001591995,0.0001216168,0.0001573496,0.2397179,0.00007334813,0.05117697,0.0001968782],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901112,0.003176801,0.00001262198,0.005471687,0.0001967306,0.0004221958,0.0001088709,0.0001054791,0.0003944109],"genre_scores_gemma":[0.9782367,0.004792173,0.00110656,0.0005054066,0.0001545446,0.0002131441,0.00005531306,0.00003145383,0.01490465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04452416,"threshold_uncertainty_score":0.7044078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02497574594991467,"score_gpt":0.3147182043274793,"score_spread":0.2897424583775646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}