{"id":"W4317510589","doi":"10.3390/ijms24031887","title":"The Problem of Host and Pathogen Genetic Variability for Developing Strategies of Universally Efficacious Vaccination against and Personalised Immunotherapy of Tuberculosis: Potential Solutions?","year":2023,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Vaccination; Tuberculosis; Immunology; Immune system; Immunotherapy; Disease; Immunity; Pathogen; Infectious disease (medical specialty); Medicine; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01273578,0.0007679117,0.002392286,0.0005087451,0.001171061,0.004013855,0.002318004,0.007267675,0.002921438],"category_scores_gemma":[0.01303015,0.0004864207,0.0009166905,0.0006344456,0.00909178,0.008379463,0.003412782,0.01295354,0.001319927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001706051,"about_ca_system_score_gemma":0.003400535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008652717,"about_ca_topic_score_gemma":0.00087641,"domain_scores_codex":[0.9968927,0.001681392,0.0002123528,0.0005158567,0.0004847495,0.0002129415],"domain_scores_gemma":[0.9925532,0.005045335,0.0008923185,0.0005809817,0.0005013049,0.0004268374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004697954,0.0003506163,0.007627601,0.001936592,0.0003004464,0.00176691,0.001939551,0.008458959,0.01195851,0.669111,0.0514483,0.2446316],"study_design_scores_gemma":[0.00005343187,0.0002777859,0.001355769,0.0006093786,0.00006184135,0.001874033,0.001402088,0.005323242,0.002222851,0.8889077,0.09778653,0.0001253251],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.009269732,0.06827825,0.1053475,0.8057334,0.006564276,0.00007182631,0.00008397834,0.0001524672,0.004498624],"genre_scores_gemma":[0.3912266,0.1453636,0.1922247,0.2314313,0.02446256,0.001007539,0.0001517992,0.0002094604,0.01392243],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01273578,"threshold_uncertainty_score":0.06735408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02165623371123989,"score_gpt":0.3227978839696179,"score_spread":0.301141650258378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}