{"id":"W4317516521","doi":"10.1021/acs.jnatprod.2c01030","title":"Thorectidiol A Isolated from the Marine Sponge <i>Dactylospongia elegans</i> Disrupts Interactions of the SARS-CoV-2 Spike Receptor Binding Domain with the Host ACE2 Receptor","year":2023,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Wistar Institute; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Philadelphia Foundation","keywords":"Stereochemistry; Sponge; Dimer; Chemistry; Receptor; Biology; Biochemistry; Organic chemistry; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009501588,0.0003127917,0.0003389764,0.00008249487,0.0003154294,0.00007269466,0.0009277659,0.0001209043,0.00002689427],"category_scores_gemma":[0.0009272642,0.0001325714,0.000240679,0.001175388,0.0002125614,0.00004629565,0.00047059,0.00107021,0.00001678345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004817377,"about_ca_system_score_gemma":0.0001617668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008850206,"about_ca_topic_score_gemma":0.000219766,"domain_scores_codex":[0.9979162,0.0003441342,0.0005058925,0.000405657,0.0004530242,0.0003750535],"domain_scores_gemma":[0.9976447,0.0001531767,0.0008019551,0.0007538823,0.0005990064,0.0000473035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001275896,0.00004755119,0.001237085,0.00001954822,0.0002974441,0.000007414374,0.0002213809,0.000005815591,0.9313601,0.00001174253,0.06416671,0.001349318],"study_design_scores_gemma":[0.0006903028,0.0004131673,0.0203903,0.0001223506,0.0001122345,0.0002418033,0.00034654,0.00001275441,0.7918599,0.00002946127,0.1855298,0.0002513455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9578801,0.001032298,0.000003579707,0.03815639,0.002262773,0.0004987633,0.00006458969,0.0000153909,0.00008608015],"genre_scores_gemma":[0.9945856,0.0004170431,0.0003779824,0.000388929,0.001943322,0.000005662375,0.00009528461,0.00004455759,0.002141585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1395002,"threshold_uncertainty_score":0.5406107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01035095573990622,"score_gpt":0.2524889960151407,"score_spread":0.2421380402752345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}