{"id":"W4317536028","doi":"10.7554/elife.81622","title":"Quantifying changes in the T cell receptor repertoire during thymic development","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"European Research Council; Centre National de la Recherche Scientifique; Agence Nationale de la Recherche; Deutsche Forschungsgemeinschaft","keywords":"Repertoire; T-cell receptor; Biology; Receptor; Cell biology; Immunology; Computational biology; T cell; Evolutionary biology; Genetics; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005459486,0.0002110506,0.0003526756,0.0004199609,0.000147371,0.0004491206,0.0003144416,0.0002936566,0.001010236],"category_scores_gemma":[0.00139352,0.0002722828,0.0002525626,0.0003454977,0.0002699932,0.0003086213,0.0002397593,0.0005250005,0.0003461706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000213733,"about_ca_system_score_gemma":0.0001390245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004894916,"about_ca_topic_score_gemma":0.0006685093,"domain_scores_codex":[0.9997484,0.00003398155,0.000009751823,0.00008762415,0.00008046236,0.00003979501],"domain_scores_gemma":[0.9992342,0.0004691368,0.0001190383,0.00006571868,0.00006026253,0.00005164121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001713801,0.00003936892,0.03099625,0.00008331914,0.00006457651,0.00006553873,0.00006963692,0.01290649,0.9398544,0.0004533693,0.00009538222,0.01520022],"study_design_scores_gemma":[0.00001324428,0.0003484552,0.235032,0.0000231404,0.0001169734,0.0005203043,0.0001330726,0.1629072,0.596063,0.002532914,0.002267077,0.00004263133],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9498367,0.0004300861,0.04793536,0.00002451958,0.000005787667,0.000009147996,0.0007020483,0.0002922498,0.000764113],"genre_scores_gemma":[0.9809864,0.0002900447,0.0171013,0.00004299993,0.000003870854,0.00002698399,0.001025254,0.00007995192,0.0004432092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001010236,"threshold_uncertainty_score":0.003379583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03366478175372981,"score_gpt":0.2467608596644723,"score_spread":0.2130960779107425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}