{"id":"W4317545893","doi":"10.1021/acs.inorgchem.2c04123","title":"Toward <sup>68</sup>Ga and <sup>64</sup>Cu Positron Emission Tomography Probes: Is H<sub>2</sub>dedpa-<i>N</i>,<i>N</i>′-pram the Missing Link for dedpa Conjugation?","year":2023,"lang":"en","type":"article","venue":"Inorganic Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia; TRIUMF","funders":"Universidade de Santiago de Compostela; Xunta de Galicia; Natural Sciences and Engineering Research Council of Canada; Ministerio de Ciencia e Innovación; TRIUMF","keywords":"Chemistry; DOTA; Chelation; Ethylenediamine; Potentiometric titration; Bifunctional; Ligand (biochemistry); Coordination sphere; Propylamine; Titration; Crystallography; Physical chemistry; Amine gas treating; Inorganic chemistry; Ion; Organic chemistry; Crystal structure; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001137442,0.0003218204,0.0001218614,0.0001638202,0.0001075649,0.0003733652,0.0003108825,0.0003512457,0.007348195],"category_scores_gemma":[0.00009388439,0.0002366874,0.0001098809,0.0001373008,0.0001681614,0.0003517953,0.0001849929,0.0004117436,0.002734513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001872167,"about_ca_system_score_gemma":0.0001466782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003527329,"about_ca_topic_score_gemma":0.0006129182,"domain_scores_codex":[0.9999565,0.000005250976,0.000001487548,0.00001053341,0.00001858968,0.000007730428],"domain_scores_gemma":[0.999965,0.000007680838,0.00000815621,0.000003636873,0.000008520582,0.000007159738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000550212,0.000006102049,0.00004951613,0.00006058482,0.000001990522,0.00007609511,0.00001453384,0.00008610132,0.9936817,0.0002279717,0.001105228,0.00463526],"study_design_scores_gemma":[0.00001100267,0.00008389277,0.0008435431,0.000007312231,0.000006766883,0.0003618015,0.00003130819,0.001391908,0.9798833,0.0001492211,0.01722117,0.000008865901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7701637,0.005073677,0.1577735,0.004052265,0.0004178305,0.0002862531,0.00296205,0.005012764,0.05425809],"genre_scores_gemma":[0.7897505,0.005871059,0.1352642,0.0009282014,0.0001306319,0.0002294359,0.00250154,0.0006874576,0.06463692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007348195,"threshold_uncertainty_score":0.02458221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02309529359529713,"score_gpt":0.2838090419756804,"score_spread":0.2607137483803833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}