{"id":"W4317553107","doi":"10.1126/sciadv.ade8039","title":"Codelivery of synergistic antimicrobials with polyelectrolyte nanocomplexes to treat bacterial biofilms and lung infections","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"University of California, San Francisco; National Institutes of Health; National Science Foundation","keywords":"Antimicrobial; Biofilm; Tobramycin; Pseudomonas aeruginosa; Antibiotics; Microbiology; Cystic fibrosis; Drug delivery; Polyelectrolyte; Drug; Chemistry; Medicine; Bacteria; Biology; Nanotechnology; Materials science; Pharmacology; Gentamicin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001869786,0.00009042549,0.0001836429,0.0003976649,0.0002250109,0.00002718159,0.00006969086,0.0000208836,0.0000371914],"category_scores_gemma":[0.00007340199,0.00006334313,0.00002218044,0.001281183,0.0005436653,0.000285473,0.00003616165,0.00004222105,0.00001759564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002599344,"about_ca_system_score_gemma":0.0001780352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001925195,"about_ca_topic_score_gemma":0.00001337964,"domain_scores_codex":[0.9991453,0.00001536411,0.0001534324,0.0002456932,0.0002094305,0.0002307398],"domain_scores_gemma":[0.9995161,0.00004832845,0.0000577732,0.0001320061,0.0001360893,0.0001097627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008618554,0.00002423626,0.002632023,0.00004617674,0.000005046414,0.000006221722,0.000113803,0.0003028041,0.9946701,0.00007625577,0.0001357624,0.001901397],"study_design_scores_gemma":[0.0006285654,0.0005574375,0.007186074,0.0001410305,0.00004285976,0.00003744113,0.0001560569,0.0003247673,0.9897867,0.000008755504,0.0009962312,0.0001341076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998236,0.0001195985,0.0001347602,0.0002077152,0.0001691159,0.0002252684,0.00001672013,0.00006736806,0.0008234294],"genre_scores_gemma":[0.9987916,0.00006334454,0.0004576938,0.0001489359,0.0000655624,0.000007900111,0.000005113415,0.000006792053,0.0004530748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004883415,"threshold_uncertainty_score":0.2583058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01027625762239504,"score_gpt":0.2858471646951171,"score_spread":0.2755709070727221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}