{"id":"W4317564834","doi":"10.1158/2159-8290.cd-22-0886","title":"Genomic Instability and Protumoral Inflammation Are Associated with Primary Resistance to Anti–PD-1 + Antiangiogenesis in Malignant Pleural Mesothelioma","year":2023,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Chugai Pharmaceutical; Aptitude Health; Foundation Medicine; Sierra Oncology; Ipsen; AstraZeneca France; PharmaMar; Daiichi Sankyo Europe; Servier; Genentech; Institut Gustave-Roussy; Astellas Pharma; Eisai; Merck Sharp and Dohme; Université Paris-Saclay; Fondation pour la Recherche Médicale; BeiGene; MSD K.K.; Agence Nationale de la Recherche; Agios Pharmaceuticals; Seerave Foundation; Astex Pharmaceuticals; Les Laboratories Pierre Fabre; Sanofi; Terumo; Exelixis; MSDAVENIR; Pfizer; Incyte; Taiho Pharmaceutical; AstraZeneca; Novocure; Boston Scientific Corporation; Relay Therapeutics; Amgen; Celgene; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Mesothelioma; Genome instability; Inflammation; Cancer research; Medicine; Primary (astronomy); Asbestos; Pathology; Biology; Internal medicine; Genetics; DNA damage; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000966856,0.0001263431,0.0002221626,0.0001173146,0.00005036142,0.00002522358,0.00004260723,0.00003383529,0.00001735539],"category_scores_gemma":[0.00002975204,0.000101093,0.00003595759,0.0003952738,0.00006951287,0.0002222285,0.00005041255,0.00004330065,0.000011022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003764818,"about_ca_system_score_gemma":0.0001139976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007070795,"about_ca_topic_score_gemma":0.0006885416,"domain_scores_codex":[0.9990796,0.00003175142,0.0001806631,0.0002885513,0.0002187356,0.0002006651],"domain_scores_gemma":[0.9996561,0.00002649991,0.00007244641,0.0001397205,0.00001787202,0.00008729562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007557204,0.00005569349,0.9764013,0.0001868837,0.00003530931,0.00006199021,0.0001120974,0.0002820257,0.02155861,0.00001123474,0.0002365421,0.0003026481],"study_design_scores_gemma":[0.0008043615,0.00005728982,0.9954011,0.0005084219,0.00004366319,0.00000157792,0.000112016,0.00003382459,0.002750356,0.00003525984,0.000115264,0.0001368473],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997393,0.0004704465,0.000004353893,0.001020533,0.0000357377,0.000647601,0.0002656658,0.0000442793,0.000118345],"genre_scores_gemma":[0.9985141,0.0001080563,0.00002735614,0.0002428573,0.00005415006,0.0001850076,0.0001851342,0.00002005597,0.000663322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01899987,"threshold_uncertainty_score":0.4122451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01464019511693807,"score_gpt":0.2443358065374779,"score_spread":0.2296956114205399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}