{"id":"W4317564834","doi":"10.1158/2159-8290.cd-22-0886","title":"Genomic Instability and Protumoral Inflammation Are Associated with Primary Resistance to Anti–PD-1 + Antiangiogenesis in Malignant Pleural Mesothelioma","year":2023,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Chugai Pharmaceutical; Aptitude Health; Foundation Medicine; Sierra Oncology; Ipsen; AstraZeneca France; PharmaMar; Daiichi Sankyo Europe; Servier; Genentech; Institut Gustave-Roussy; Astellas Pharma; Eisai; Merck Sharp and Dohme; Université Paris-Saclay; Fondation pour la Recherche Médicale; BeiGene; MSD K.K.; Agence Nationale de la Recherche; Agios Pharmaceuticals; Seerave Foundation; Astex Pharmaceuticals; Les Laboratories Pierre Fabre; Sanofi; Terumo; Exelixis; MSDAVENIR; Pfizer; Incyte; Taiho Pharmaceutical; AstraZeneca; Novocure; Boston Scientific Corporation; Relay Therapeutics; Amgen; Celgene; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Mesothelioma; Genome instability; Inflammation; Cancer research; Medicine; Primary (astronomy); Asbestos; Pathology; Biology; Internal medicine; Genetics; DNA damage; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001231267,0.0001205317,0.0002108041,0.0002853655,0.0001325515,0.0001984722,0.00007832301,0.0001491129,0.001002334],"category_scores_gemma":[0.0002939008,0.000105688,0.0001169307,0.000185908,0.000143629,0.00008670875,0.0001372736,0.0001838147,0.0001014916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001103808,"about_ca_system_score_gemma":0.00008311069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001541558,"about_ca_topic_score_gemma":0.0002625262,"domain_scores_codex":[0.9998934,0.00002286192,0.00001166005,0.00003153709,0.0000222073,0.00001834327],"domain_scores_gemma":[0.9997877,0.00004013089,0.0000992645,0.0000146123,0.00001537473,0.00004286513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003215654,0.0001456678,0.6549804,0.0001302067,0.0001200109,0.00142757,0.0001982963,0.0004580934,0.3188361,0.00007320392,0.0001927791,0.0202219],"study_design_scores_gemma":[0.00003833145,0.001163805,0.9759431,0.000005003644,0.00008510808,0.004544954,0.00007743092,0.0006790713,0.01680024,0.00008066482,0.0005773893,0.000004734333],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994708,0.0002673021,0.00009224896,0.00001025475,0.000001069956,0.000004407773,0.00004989816,0.000003780998,0.0001002728],"genre_scores_gemma":[0.9997273,0.00005449976,0.00007405636,0.000007381849,0.000003390336,0.000004207238,0.00006140273,7.734882e-7,0.00006701604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001002334,"threshold_uncertainty_score":0.003353179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01464019511693807,"score_gpt":0.2443358065374779,"score_spread":0.2296956114205399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}