{"id":"W4317565732","doi":"10.1200/jco.22.01229","title":"Impact of the HLA Immunopeptidome on Survival of Leukemia Patients After Unrelated Donor Transplantation","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Office of Naval Research; Legend Biotech; Pharmacyclics; Sanofi Genzyme; Takeda Oncology; Health Resources and Services Administration; MorphoSys; José Carreras Leukämie-Stiftung; TG Therapeutics; bluebird bio; Kiadis Pharma; Omeros Corporation; Astellas Pharma; Adaptive Biotechnologies; Pfizer; Incyte; Medac; Jazz Pharmaceuticals; Actinium Pharmaceuticals; CareDx; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; CSL Behring; HistoGenetics; Atara Biotherapeutics; Daiichi Sankyo Europe; National Cancer Institute; Gilead Sciences; Sanofi; Amgen; StemCyte; Deutsche Forschungsgemeinschaft; GlaxoSmithKline; Mallinckrodt Pharmaceuticals; Astellas Pharma US","keywords":"Medicine; Human leukocyte antigen; Hazard ratio; Transplantation; Proportional hazards model; Hematopoietic cell; Immunology; Graft-versus-host disease; Hematopoietic stem cell transplantation; Internal medicine; Oncology; Antigen; Haematopoiesis; Biology; Stem cell; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005891824,0.0001146641,0.0001786533,0.0001848584,0.0002023639,0.0003741978,0.0001370109,0.000197176,0.0008672089],"category_scores_gemma":[0.001879092,0.00004715359,0.0002068824,0.000213698,0.0002209887,0.0003070002,0.0003854585,0.0003214347,0.0001122049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002370998,"about_ca_system_score_gemma":0.0002133519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005498346,"about_ca_topic_score_gemma":0.0008410272,"domain_scores_codex":[0.9996477,0.000128112,0.00002950155,0.00006329314,0.00005492954,0.00007637989],"domain_scores_gemma":[0.9985254,0.0003811543,0.0006791643,0.00009029806,0.00006069128,0.0002632797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001060252,0.0000330953,0.991729,0.000007086798,0.00003359187,0.00008363619,0.00004326019,0.0002308096,0.0009279007,0.00003485408,0.00004114231,0.005775437],"study_design_scores_gemma":[0.00001240138,0.0005104003,0.9974759,0.000004771437,0.00002301226,0.0003971146,0.0001058372,0.000710801,0.0004313052,0.00008693237,0.0002377219,0.000003772113],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995008,0.0001884771,0.00006585418,0.00002306234,0.000002851002,0.000001317707,0.00004265499,0.000001418447,0.0001735564],"genre_scores_gemma":[0.9998494,0.00002321244,0.00001856774,0.000009625672,0.000003472983,8.642261e-7,0.00005990129,4.64552e-7,0.00003448118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008672089,"threshold_uncertainty_score":0.003115892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04495652827376074,"score_gpt":0.3763310075641685,"score_spread":0.3313744792904078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}