{"id":"W4317565732","doi":"10.1200/jco.22.01229","title":"Impact of the HLA Immunopeptidome on Survival of Leukemia Patients After Unrelated Donor Transplantation","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Office of Naval Research; Legend Biotech; Pharmacyclics; Sanofi Genzyme; Takeda Oncology; Health Resources and Services Administration; MorphoSys; José Carreras Leukämie-Stiftung; TG Therapeutics; bluebird bio; Kiadis Pharma; Omeros Corporation; Astellas Pharma; Adaptive Biotechnologies; Pfizer; Incyte; Medac; Jazz Pharmaceuticals; Actinium Pharmaceuticals; CareDx; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; CSL Behring; HistoGenetics; Atara Biotherapeutics; Daiichi Sankyo Europe; National Cancer Institute; Gilead Sciences; Sanofi; Amgen; StemCyte; Deutsche Forschungsgemeinschaft; GlaxoSmithKline; Mallinckrodt Pharmaceuticals; Astellas Pharma US","keywords":"Medicine; Human leukocyte antigen; Hazard ratio; Transplantation; Proportional hazards model; Hematopoietic cell; Immunology; Graft-versus-host disease; Hematopoietic stem cell transplantation; Internal medicine; Oncology; Antigen; Haematopoiesis; Biology; Stem cell; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001162018,0.00009808299,0.000491482,0.00005679747,0.00001971652,0.000003479905,0.0002466201,0.0002832444,0.00001691279],"category_scores_gemma":[0.0005466648,0.00005501516,0.0006081744,0.0001418983,0.00008286287,0.000008282755,0.00005332693,0.0002843556,0.000004347533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003393397,"about_ca_system_score_gemma":0.0005069217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001397309,"about_ca_topic_score_gemma":0.0000063335,"domain_scores_codex":[0.9978706,0.0002206926,0.001525786,0.00007696995,0.0001777748,0.0001281749],"domain_scores_gemma":[0.9979002,0.0002231726,0.001360477,0.0001947047,0.0002703191,0.00005106169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02382374,0.001829449,0.8811066,0.0001686316,0.002158899,0.00001536795,0.0005943177,0.00478282,0.03772941,0.00006159421,0.00344025,0.04428894],"study_design_scores_gemma":[0.00350289,0.007362317,0.9856374,0.00004920332,0.00008540747,0.000006367349,0.00003968538,0.00009483597,0.002310374,0.00003649,0.0008125588,0.00006253048],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985732,0.00006095298,0.0000207813,0.00008265641,0.0005901342,0.00009869694,0.00002490845,0.000001372029,0.0005472428],"genre_scores_gemma":[0.9988495,0.0007999142,0.00007049558,0.0000568959,0.0001075807,0.000001601484,0.0000233434,0.000009382012,0.00008127847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1045308,"threshold_uncertainty_score":0.2243453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04495652827376074,"score_gpt":0.3763310075641685,"score_spread":0.3313744792904078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}