{"id":"W4317567214","doi":"10.1093/eurheartj/ehac818","title":"Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity","year":2023,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Brigham and Women's Hospital; Heart and Stroke Foundation of Canada","keywords":"Calcification; Fibrosis; Medicine; Inflammation; Phenotype; Interstitial cell; Aortic valve; Cardiac fibrosis; valvular heart disease; Myofibroblast; Calcinosis; Pathology; Internal medicine; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002641269,0.00011289,0.0001661447,0.0001189261,0.0001046363,0.00006315969,0.00003543673,0.00001609776,0.00003645114],"category_scores_gemma":[0.00006033205,0.00009920413,0.0003296111,0.0001505844,0.00003498032,0.00009365057,0.00004196246,0.0001701127,0.0001195595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005506174,"about_ca_system_score_gemma":0.00004371324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001301473,"about_ca_topic_score_gemma":9.669703e-7,"domain_scores_codex":[0.99898,0.0001689301,0.0002352513,0.0002108631,0.0001864737,0.0002185171],"domain_scores_gemma":[0.9993621,0.00003263502,0.00006162268,0.0001334519,0.00002901122,0.0003812125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001904074,0.000153041,0.9805226,0.00005056011,0.00007927063,0.00011607,0.0002043296,0.00001410448,0.01268401,5.033236e-7,0.003307985,0.002677097],"study_design_scores_gemma":[0.0008978244,0.0001151599,0.9961832,0.0001442632,0.0001437625,0.0000221894,0.0001092963,0.0001194376,0.001749116,0.000006515959,0.0004248633,0.00008434006],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978628,0.001212984,0.0000274768,0.0002691584,0.0001710979,0.0001335778,0.00002841174,0.00003339835,0.0002611502],"genre_scores_gemma":[0.998894,0.0005350263,0.00004255037,0.0001510704,0.0001901808,0.000003468636,0.00004699413,0.00002475261,0.0001119251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01566061,"threshold_uncertainty_score":0.4045427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03329577102616098,"score_gpt":0.3555980359412396,"score_spread":0.3223022649150786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}