{"id":"W4317567214","doi":"10.1093/eurheartj/ehac818","title":"Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity","year":2023,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Brigham and Women's Hospital; Heart and Stroke Foundation of Canada","keywords":"Calcification; Fibrosis; Medicine; Inflammation; Phenotype; Interstitial cell; Aortic valve; Cardiac fibrosis; valvular heart disease; Myofibroblast; Calcinosis; Pathology; Internal medicine; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002864431,0.0002759163,0.0002877119,0.0003247679,0.0002040799,0.0005440934,0.0001669322,0.000365882,0.001400481],"category_scores_gemma":[0.0001607975,0.0001400203,0.0002833669,0.0001449092,0.0003166056,0.0002508486,0.0003592157,0.0005773249,0.0002809772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003191312,"about_ca_system_score_gemma":0.0001882404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004028479,"about_ca_topic_score_gemma":0.0009530318,"domain_scores_codex":[0.9997947,0.00002590065,0.0000187282,0.00004994633,0.00006917611,0.00004168085],"domain_scores_gemma":[0.9997965,0.00002639887,0.00005995726,0.00001564731,0.00002380947,0.00007776685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001594558,0.00002071142,0.0007515086,0.0001092361,0.00001200201,0.00005042665,0.00002198358,0.00006266744,0.9968153,0.00009455303,0.00008445865,0.00181774],"study_design_scores_gemma":[0.0000544819,0.0004928147,0.02764446,0.00003188864,0.00008205483,0.0008214539,0.0001163573,0.002080893,0.96159,0.0001736988,0.006896873,0.0000150387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912593,0.002685257,0.003661211,0.0002089023,0.00005396253,0.00003465558,0.0005400532,0.0001906601,0.001365906],"genre_scores_gemma":[0.9941105,0.001162555,0.002313373,0.0001532508,0.00001642937,0.00003962444,0.000553551,0.00003706905,0.001613622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001400481,"threshold_uncertainty_score":0.004685044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03329577102616098,"score_gpt":0.3555980359412396,"score_spread":0.3223022649150786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}