{"id":"W4317567550","doi":"10.1007/s12035-023-03227-9","title":"CNTNAP2 Protein Is Degraded by the Ubiquitin–Proteasome System and the Macroautophagy-Lysosome Pathway","year":2023,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"University of British Columbia","keywords":"Lysosome; Biology; Transmembrane protein; Protein degradation; Proteasome; Ubiquitin; Neuroscience; Cell biology; Neurodegeneration; Gene; Genetics; Biochemistry; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001833813,0.000388998,0.0003058209,0.0003799664,0.0004653623,0.0005671522,0.0002512663,0.0004580159,0.001065685],"category_scores_gemma":[0.0002720407,0.0002193523,0.0004437949,0.0001699839,0.0003226779,0.0006129313,0.0002901728,0.0005999563,0.0003418351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001026842,"about_ca_system_score_gemma":0.0004522292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001907953,"about_ca_topic_score_gemma":0.002657003,"domain_scores_codex":[0.9997969,0.00001848031,0.00001654549,0.00005562446,0.00007469359,0.00003768312],"domain_scores_gemma":[0.9998103,0.00002184276,0.00005250261,0.00001188926,0.00003844622,0.00006495758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004531616,0.00001842815,0.002056797,0.00009717148,0.00004250877,0.001243696,0.00002176567,0.00009678951,0.9934181,0.000469721,0.000262413,0.00181932],"study_design_scores_gemma":[0.0000609229,0.000153712,0.05605435,0.00002584131,0.00007218425,0.009803625,0.00007909766,0.003599374,0.919912,0.0006632676,0.009547516,0.00002798697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771686,0.01374443,0.004773813,0.0004197516,0.0001510745,0.00002927474,0.0006381166,0.00007728682,0.002997634],"genre_scores_gemma":[0.9907143,0.002158611,0.002251487,0.000121812,0.00005324011,0.00002938673,0.001129963,0.00002955294,0.003511532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001907953,"threshold_uncertainty_score":0.007450283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005547820646226543,"score_gpt":0.1908129458991903,"score_spread":0.1852651252529637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}