{"id":"W4317567550","doi":"10.1007/s12035-023-03227-9","title":"CNTNAP2 Protein Is Degraded by the Ubiquitin–Proteasome System and the Macroautophagy-Lysosome Pathway","year":2023,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"University of British Columbia","keywords":"Lysosome; Biology; Transmembrane protein; Protein degradation; Proteasome; Ubiquitin; Neuroscience; Cell biology; Neurodegeneration; Gene; Genetics; Biochemistry; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003791319,0.0002534746,0.0002558672,0.00004276529,0.0002301325,0.00004120827,0.0003000007,0.0002387483,0.00001028706],"category_scores_gemma":[0.00003370347,0.0001558675,0.000195796,0.0002103193,0.0004322766,0.000002938528,0.0001489123,0.0002183503,0.00004245207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009086056,"about_ca_system_score_gemma":0.00004483525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000230616,"about_ca_topic_score_gemma":0.000002962279,"domain_scores_codex":[0.9982987,0.0003386871,0.0002754575,0.0005451838,0.0001235786,0.0004183772],"domain_scores_gemma":[0.9991761,0.00002151028,0.0000969505,0.0005800054,0.00004885148,0.00007659105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001665823,0.00001427831,0.0001552988,0.00004638143,0.00006856376,0.00004531335,0.00005648964,0.000005228322,0.9973286,0.001520759,0.0003550352,0.0002375157],"study_design_scores_gemma":[0.001763002,0.0002622371,0.000796558,0.00001938501,0.00005442841,0.0002048649,0.00009607918,0.0002907345,0.951341,0.0001483382,0.04477447,0.00024892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926414,0.001485477,0.001554696,0.00254563,0.00013902,0.001123641,0.00005856916,0.00007703695,0.0003745228],"genre_scores_gemma":[0.9955407,0.0001128984,0.00001927836,0.001438549,0.00008391233,0.0002405805,0.001100448,0.00004430447,0.00141927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04598757,"threshold_uncertainty_score":0.6356094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005547820646226543,"score_gpt":0.1908129458991903,"score_spread":0.1852651252529637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}