{"id":"W4317567837","doi":"10.1093/plcell/koad013","title":"Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics","year":2023,"lang":"en","type":"article","venue":"The Plant Cell","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; National Research Foundation of Korea; National Research Foundation; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","keywords":"Biology; Phosphoproteomics; Signal transduction; Cell biology; Kinase; Arabidopsis; Biochemistry; Protein phosphorylation; Protein kinase A; Mutant; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004131168,0.0001093557,0.0001135089,0.00001713954,0.0002499578,0.00001342179,0.0001338546,0.0001116014,0.000002347628],"category_scores_gemma":[0.000033913,0.00006127806,0.00005050694,0.000220002,0.0001175615,9.698688e-7,0.0001802773,0.0001420399,0.000004604341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003860118,"about_ca_system_score_gemma":0.00002194211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005380817,"about_ca_topic_score_gemma":0.000006521705,"domain_scores_codex":[0.9993365,0.00004897972,0.0001622833,0.0001527527,0.00007219212,0.0002272546],"domain_scores_gemma":[0.9996147,0.00007892581,0.00009722431,0.0001576679,0.00002704451,0.00002448277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000293948,0.000007866575,0.0006894278,0.00003090434,0.00007556077,0.000003459926,0.0003454692,0.003358967,0.9945132,0.00000849212,0.0008044562,0.0001327956],"study_design_scores_gemma":[0.0004831401,0.00006370354,0.000397223,0.000126628,0.00006683894,0.00001699213,0.001577224,0.01203223,0.9797321,0.00008220643,0.005199367,0.0002223478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926235,0.006529881,0.00008151131,0.0002418205,0.0001777172,0.0001599692,0.00003531596,0.00001664267,0.0001336623],"genre_scores_gemma":[0.9962208,0.002898525,0.0003578292,0.0001337114,0.0001697621,0.000002262735,0.00006046611,0.00001457172,0.0001420283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0147811,"threshold_uncertainty_score":0.2498847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02305065916870816,"score_gpt":0.2082180987619718,"score_spread":0.1851674395932636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}