{"id":"W4317567916","doi":"10.1007/s00216-023-04545-6","title":"Bottom-up proteomics analysis for adduction of the broad-spectrum herbicide atrazine to histone","year":2023,"lang":"en","type":"article","venue":"Analytical and Bioanalytical Chemistry","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Environment and Climate Change Canada","funders":"Environment and Climate Change Canada","keywords":"Atrazine; Chemistry; Histone; Histone H3; Biochemistry; Mass spectrometry; Chromatography; Biology; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002119094,0.0006744193,0.0004017199,0.0004027865,0.0002523958,0.000253875,0.0003024816,0.0003581794,0.0008153458],"category_scores_gemma":[0.0002274631,0.0002066637,0.0004114053,0.00027638,0.000167738,0.0002596509,0.0003499852,0.0004984831,0.0005205572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002244234,"about_ca_system_score_gemma":0.0002713232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008275183,"about_ca_topic_score_gemma":0.001508731,"domain_scores_codex":[0.9997472,0.00002310585,0.000009516259,0.00006890315,0.0001176225,0.00003356439],"domain_scores_gemma":[0.9998645,0.0000202276,0.00002820241,0.0000110865,0.00005328283,0.00002262621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000179972,0.00000625201,0.0001721061,0.00002238807,0.000005842478,0.00002283569,0.000006381372,0.00001804411,0.9990233,0.000007080281,0.00002258093,0.0006752753],"study_design_scores_gemma":[0.000004458951,0.0001336612,0.006860448,0.000006010495,0.00003052605,0.0002774481,0.00003519671,0.001713427,0.9894472,0.00002620854,0.00145137,0.00001384696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9288222,0.003391714,0.06315067,0.0002419904,0.0001229948,0.0001961031,0.001819389,0.0006092191,0.001645653],"genre_scores_gemma":[0.8633928,0.003986261,0.1202392,0.000497042,0.00006206791,0.0002003669,0.003896098,0.0002059352,0.007520207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008275183,"threshold_uncertainty_score":0.002727568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009667788533270908,"score_gpt":0.2604844779674318,"score_spread":0.250816689434161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}