{"id":"W4317568027","doi":"10.1093/cid/ciad020","title":"Long-Acting Cabotegravir and Rilpivirine Dosed Every 2 Months in Adults With Human Immunodeficiency Virus 1 Type 1 Infection: 152-Week Results From ATLAS-2M, a Randomized, Open-Label, Phase 3b, Noninferiority Study","year":2023,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Regina","funders":"Janssen Research and Development; Gilead Sciences; Insmed; ViiV Healthcare; National Institutes of Health; Pfizer","keywords":"Rilpivirine; Medicine; Tolerability; Human immunodeficiency virus (HIV); Dosing; Regimen; Internal medicine; Viral load; Adverse effect; Virology; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001365692,0.0005354868,0.001788578,0.0003322916,0.0004592542,0.0002036699,0.0001758735,0.0001845148,0.00009653126],"category_scores_gemma":[0.002566446,0.0004035819,0.0001681059,0.001258158,0.0003956702,0.0003727849,0.0003479709,0.0005853006,0.0001479834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001826504,"about_ca_system_score_gemma":0.0004233442,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00667245,"about_ca_topic_score_gemma":0.005936269,"domain_scores_codex":[0.995571,0.0007091278,0.001588278,0.001150489,0.0004474739,0.0005335996],"domain_scores_gemma":[0.9960342,0.002155392,0.0004602021,0.0006760301,0.000248114,0.0004260844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.09621435,0.02314022,0.8681067,0.00006621508,0.0008532597,0.001301651,0.001102215,0.00001983324,0.00002545511,0.000007141018,0.0003665301,0.008796485],"study_design_scores_gemma":[0.4177651,0.004052413,0.5753738,0.0005508928,0.000848829,0.000009211981,0.0002823853,0.0004152638,0.00001720977,0.00008921683,0.000180042,0.0004156503],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933968,0.0004249926,0.00001633087,0.0001921817,0.0004213208,0.003986249,0.0001455051,0.0004150381,0.001001591],"genre_scores_gemma":[0.9965525,0.0009280244,0.00003555156,0.00009538521,0.0002080822,0.0003934006,0.0007268005,0.00006309297,0.0009971412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3215508,"threshold_uncertainty_score":0.9999422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06474784941476527,"score_gpt":0.4037233714721519,"score_spread":0.3389755220573867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}