{"id":"W4317602525","doi":"10.21203/rs.3.rs-2418444/v1","title":"Ligand-independent Activation of Platelet-derived Growth Factor Receptor β promotes contraction of retinal pigment epithelial cells","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Retinal and Macular Surgery","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Science Foundation of Tianjin City; Sanming Project of Medicine in Shenzhen; Shanxi Scholarship Council of China; National Natural Science Foundation of China; Health Commission of Shanxi Province","keywords":"Proliferative vitreoretinopathy; Cell biology; Protein kinase B; Platelet-derived growth factor receptor; PI3K/AKT/mTOR pathway; Growth factor; Chemistry; Platelet-derived growth factor; Signal transduction; Cancer research; Biology; Retinal; Receptor; Retinal detachment; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001832286,0.000294181,0.0008465779,0.0006745299,0.00008664816,0.00003309409,0.0002113779,0.0005077239,0.0002417462],"category_scores_gemma":[0.001359605,0.0002463392,0.0003881741,0.0003541519,0.0001803927,0.00007545094,0.0004250741,0.001540586,0.00006634124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003255069,"about_ca_system_score_gemma":0.0007506452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008956764,"about_ca_topic_score_gemma":0.000008217655,"domain_scores_codex":[0.9953786,0.0004522553,0.0007907027,0.0006189681,0.002239669,0.0005198108],"domain_scores_gemma":[0.9963315,0.0006640688,0.0004991135,0.0005193983,0.001759293,0.0002266862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002257443,0.0004756776,0.002603195,0.006097471,0.0002677537,0.00005472757,0.0006247952,0.0000159161,0.9837884,0.00005193094,0.0007096015,0.00305306],"study_design_scores_gemma":[0.0008691365,0.0008605262,0.03587373,0.003336939,0.00003788769,0.000006022578,0.0004129264,0.00009398837,0.9575287,0.0003934375,0.0004055629,0.0001811282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947938,0.00008613877,0.0004704905,0.001184326,0.0004826417,0.002369555,0.0003369488,0.00007643662,0.0001996343],"genre_scores_gemma":[0.9967731,0.001187648,0.000228195,0.000007191389,0.0004082192,0.0001600841,0.0004305926,0.00006810156,0.0007368585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03327053,"threshold_uncertainty_score":0.9999989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07530728542261247,"score_gpt":0.3618237406049052,"score_spread":0.2865164551822927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}