{"id":"W4317602525","doi":"10.21203/rs.3.rs-2418444/v1","title":"Ligand-independent Activation of Platelet-derived Growth Factor Receptor β promotes contraction of retinal pigment epithelial cells","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Retinal and Macular Surgery","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Science Foundation of Tianjin City; Sanming Project of Medicine in Shenzhen; Shanxi Scholarship Council of China; National Natural Science Foundation of China; Health Commission of Shanxi Province","keywords":"Proliferative vitreoretinopathy; Cell biology; Protein kinase B; Platelet-derived growth factor receptor; PI3K/AKT/mTOR pathway; Growth factor; Chemistry; Platelet-derived growth factor; Signal transduction; Cancer research; Biology; Retinal; Receptor; Retinal detachment; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001013762,0.0001790684,0.0001852388,0.0001210915,0.00009477381,0.0001912044,0.00008135182,0.0001665206,0.00129487],"category_scores_gemma":[0.00009545696,0.00007763858,0.0002789278,0.00007445527,0.0000993547,0.00009153423,0.0001320158,0.0004860218,0.00030699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001030874,"about_ca_system_score_gemma":0.000114529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000212173,"about_ca_topic_score_gemma":0.000221959,"domain_scores_codex":[0.9998798,0.00002123449,0.00001288585,0.00002154503,0.00003484195,0.00002970596],"domain_scores_gemma":[0.9999434,0.000009199332,0.00001339852,0.000009323105,0.000007951145,0.00001677136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001799452,0.00004694353,0.0003950773,0.00005063337,0.000008507596,0.000132895,0.00001063128,0.00001981567,0.997319,0.00005434484,0.000114943,0.001667142],"study_design_scores_gemma":[0.00006037565,0.0006959937,0.03051021,0.00001246483,0.00004134212,0.001447763,0.00007360279,0.001039523,0.9612718,0.00009378939,0.004748499,0.000004705656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934189,0.002935455,0.001453474,0.0001466129,0.00007100922,0.00002239172,0.0002495916,0.00006095949,0.00164159],"genre_scores_gemma":[0.9970905,0.0008207338,0.0004222834,0.00007686297,0.00001353597,0.00002665225,0.00023673,0.000006706879,0.001306072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00129487,"threshold_uncertainty_score":0.004331827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07530728542261247,"score_gpt":0.3618237406049052,"score_spread":0.2865164551822927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}