{"id":"W4317603005","doi":"10.1101/2023.01.19.524784","title":"Extremely potent pan-sarbecovirus neutralizing antibodies generated by immunization of macaques with an AS03-adjuvanted monovalent subunit vaccine against SARS-CoV-2","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"SLAC National Accelerator Laboratory; University of Louisiana at Lafayette; National Institute of General Medical Sciences; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill; Basic Energy Sciences; Bill and Melinda Gates Foundation; Office of Science; National Cancer Institute; National Institutes of Health; GlaxoSmithKline; Biological and Environmental Research; Argonne National Laboratory; U.S. Department of Energy","keywords":"Neutralization; Antibody; Potency; Virology; Vaccination; Monoclonal antibody; Antigen; Immunization; Epitope; Biology; Chemistry; Immunology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021424,0.0003230307,0.0001869754,0.0002634583,0.0001315424,0.0001897672,0.0001427613,0.0003223901,0.0008084259],"category_scores_gemma":[0.0001761128,0.0001201997,0.0001759998,0.00007123999,0.0001402756,0.0001291352,0.000144384,0.0004973988,0.0001724309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002150343,"about_ca_system_score_gemma":0.0001370128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001153894,"about_ca_topic_score_gemma":0.001719687,"domain_scores_codex":[0.9998858,0.00001491973,0.000006269951,0.0000217579,0.00002442747,0.00004676569],"domain_scores_gemma":[0.9999044,0.00001762998,0.00001802606,0.00001030517,0.00002662824,0.00002308261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009774737,0.00006503,0.0009268429,0.00002405805,0.000008462343,0.00004585812,0.00003044856,0.00005754437,0.9956071,0.00003334363,0.00005137256,0.003052193],"study_design_scores_gemma":[0.0001322366,0.005320203,0.05560637,0.00003038985,0.00008355515,0.001414844,0.0001277555,0.00226627,0.9277707,0.000153036,0.007081141,0.00001344414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981307,0.0003993539,0.0008098586,0.00003297322,0.00001214161,0.00003258482,0.00007272761,0.00002625482,0.0004833362],"genre_scores_gemma":[0.996797,0.0003131717,0.001099057,0.00009027261,0.00001529844,0.00003372572,0.0003975442,0.000007779391,0.001246152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001153894,"threshold_uncertainty_score":0.002704442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05590175487527697,"score_gpt":0.3066263619018205,"score_spread":0.2507246070265435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}