{"id":"W4317632796","doi":"10.1016/j.bmcl.2023.129150","title":"Thermal treatment affects aptamers’ structural profiles","year":2023,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Brock University","funders":"","keywords":"Aptamer; Chemistry; Circular dichroism; Sonication; High-performance liquid chromatography; Elution; Chromatography; Biophysics; Analytical Chemistry (journal); Crystallography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002322993,0.000279207,0.0002025649,0.0001725548,0.0002275177,0.0003373686,0.0002094337,0.0004446083,0.006424957],"category_scores_gemma":[0.0008672515,0.0002456764,0.0002500432,0.0001921463,0.0002440275,0.0003822056,0.0001588489,0.0005888626,0.001436291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002105006,"about_ca_system_score_gemma":0.000152868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003886814,"about_ca_topic_score_gemma":0.0004818812,"domain_scores_codex":[0.9996595,0.00004798646,0.00002300407,0.000101861,0.00007046547,0.00009716902],"domain_scores_gemma":[0.9996791,0.0001060643,0.00005772294,0.00004103676,0.00006733729,0.00004876536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001695699,0.00002007251,0.0002942978,0.00002713654,0.00001133472,0.00003455587,0.00002782018,0.0002601276,0.9968959,0.0001071229,0.0001019589,0.002050159],"study_design_scores_gemma":[0.000008544748,0.0001763897,0.003935924,0.0000046865,0.00001965671,0.0001426406,0.00003076087,0.001170568,0.9930093,0.00007187639,0.001418047,0.00001162756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921017,0.0008805512,0.003603064,0.0000966666,0.00006521082,0.0000218471,0.0002259155,0.0001157777,0.002889285],"genre_scores_gemma":[0.9971766,0.0001664133,0.000708502,0.0000917965,0.000006407747,0.00001661748,0.0001742336,0.00003992502,0.001619437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006424957,"threshold_uncertainty_score":0.02149367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00992314456901641,"score_gpt":0.2574685674104764,"score_spread":0.24754542284146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}