{"id":"W4317660745","doi":"10.1016/j.ajpc.2022.100403","title":"EFFICACY AND SAFETY OF INCLISIRAN BY BASELINE BODY MASS INDEX: A POST HOC POOLED ANALYSIS OF THE ORION-9, ORION-10 AND ORION-11 PHASE III RANDOMIZED CONTROLLED TRIALS","year":2023,"lang":"en","type":"article","venue":"American Journal of Preventive Cardiology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Body mass index; Placebo; Post-hoc analysis; Medicine; Dosing; Adverse effect; Internal medicine; Dyslipidemia; Randomized controlled trial; Obesity; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.02278906,0.0002955792,0.0109693,0.000732274,0.0001020654,0.000009844529,0.0001755918,0.0001272986,0.00006511567],"category_scores_gemma":[0.008933551,0.0001622763,0.003474348,0.00144072,0.0009313466,0.00006190545,0.0001019855,0.0003463411,4.671093e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006534817,"about_ca_system_score_gemma":0.0004122844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000239838,"about_ca_topic_score_gemma":0.000008521786,"domain_scores_codex":[0.9876481,0.008346196,0.002748495,0.0003215452,0.00063176,0.0003038813],"domain_scores_gemma":[0.9901081,0.004710471,0.003432465,0.0004667818,0.001039519,0.0002426306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.773059,0.0003381365,0.008423067,0.0001325016,0.1232582,0.0001194203,0.0007397651,0.0003125538,0.02069806,0.00009950036,0.000610707,0.07220913],"study_design_scores_gemma":[0.8871772,0.004474602,0.03314003,0.0003885132,0.06908754,0.0002637295,0.002118909,0.0008845583,0.000560888,0.0001000337,0.001511806,0.0002921663],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826344,0.005615087,0.007993414,0.001049117,0.0002335396,0.002235721,0.0001834627,0.00001037199,0.00004490763],"genre_scores_gemma":[0.9934101,0.005771472,0.0001522678,0.0001410452,0.0003001552,0.00003558599,0.0000568407,0.00002261963,0.0001098983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1141183,"threshold_uncertainty_score":0.9994146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009984804300904617,"score_gpt":0.3106337832131645,"score_spread":0.3006489789122599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}