{"id":"W4317678901","doi":"10.1002/adma.202209624","title":"Unsaturated, Trialkyl Ionizable Lipids are Versatile Lipid‐Nanoparticle Components for Therapeutic and Vaccine Applications","year":2023,"lang":"en","type":"article","venue":"Advanced Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"QLT (Canada)","funders":"","keywords":"Potency; Liposome; Lipid bilayer; Lipid A; Gene silencing; Chemistry; Biochemistry; Pharmacology; Biology; Immunology; Gene; Membrane; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001489115,0.0001206674,0.0001710158,0.00003213213,0.000110881,0.00004144046,0.0001061342,0.00007459917,0.00002675173],"category_scores_gemma":[0.00003223015,0.0001106066,0.00003186012,0.00009492211,0.00002084731,0.00001007991,0.00006054343,0.00001934524,0.00004728798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008731921,"about_ca_system_score_gemma":0.00001678466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007248683,"about_ca_topic_score_gemma":0.000007097548,"domain_scores_codex":[0.9992096,0.00002924081,0.0001994264,0.0002798261,0.00006250419,0.0002193553],"domain_scores_gemma":[0.9995018,0.00002327166,0.00008992864,0.0002334931,0.0001030987,0.00004840318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003630783,0.00002276999,0.00007515521,0.00002914704,0.00003221786,3.24288e-7,0.00001651334,0.00007196141,0.9954159,0.00004686419,0.001896612,0.002029506],"study_design_scores_gemma":[0.00126968,0.0001870284,0.0009548817,0.00001506692,0.00002072433,0.000002041699,0.00006722529,0.00003866247,0.9235801,0.0003661339,0.07336189,0.0001366385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975537,0.0002911012,0.0006916817,0.0003246973,0.0003471678,0.0005799729,0.0001451109,0.00004541532,0.00002115221],"genre_scores_gemma":[0.9969677,0.0006847522,0.000307945,0.0002752152,0.0003027189,0.0004020448,0.0003891399,0.00002309907,0.0006473499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07183582,"threshold_uncertainty_score":0.4510406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205870075014635,"score_gpt":0.2768926178494616,"score_spread":0.256305610347998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}