{"id":"W4317678901","doi":"10.1002/adma.202209624","title":"Unsaturated, Trialkyl Ionizable Lipids are Versatile Lipid‐Nanoparticle Components for Therapeutic and Vaccine Applications","year":2023,"lang":"en","type":"article","venue":"Advanced Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"QLT (Canada)","funders":"","keywords":"Potency; Liposome; Lipid bilayer; Lipid A; Gene silencing; Chemistry; Biochemistry; Pharmacology; Biology; Immunology; Gene; Membrane; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002069408,0.0004462911,0.0001977142,0.0003030849,0.0001548541,0.0003628503,0.0001495762,0.0002676782,0.001183086],"category_scores_gemma":[0.0001737766,0.0001528109,0.0002036251,0.0002282854,0.0002216232,0.0003283469,0.0003980787,0.0002908322,0.0005654047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000309417,"about_ca_system_score_gemma":0.0002471134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003051953,"about_ca_topic_score_gemma":0.0005695172,"domain_scores_codex":[0.9998968,0.00002181611,0.0000116092,0.00002040516,0.00002922772,0.0000201926],"domain_scores_gemma":[0.9999233,0.00001281399,0.00003490745,0.000004142321,0.00001100208,0.00001373786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009505304,0.00001070536,0.000192547,0.0000724647,0.000004547785,0.00003983113,0.00001439806,0.0001855307,0.9957572,0.0001500872,0.00002329386,0.003454265],"study_design_scores_gemma":[0.00001870269,0.0003409802,0.0005511499,0.000008288576,0.00001610704,0.0001536856,0.00002207999,0.0003932875,0.9939074,0.00007615974,0.004504744,0.000007400301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748584,0.005590551,0.01433746,0.000200774,0.00003349765,0.0001056234,0.0003507923,0.0001532138,0.004369715],"genre_scores_gemma":[0.9802388,0.003363029,0.01096296,0.000102352,0.00001313767,0.0001099875,0.0003590368,0.0000327765,0.004818158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001183086,"threshold_uncertainty_score":0.003957868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205870075014635,"score_gpt":0.2768926178494616,"score_spread":0.256305610347998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}