{"id":"W4317698015","doi":"10.1002/cpt.2854","title":"<scp><i>ABCB1</i></scp> Gene Variants and Antidepressant Treatment Outcomes: A Systematic Review and Meta‐Analysis Including Results from the <scp>CAN‐BIND</scp>‐1 Study","year":2023,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Douglas Mental Health University Institute; McGill University; Simon Fraser University; St. Joseph’s Healthcare Hamilton; Royal Ottawa Mental Health Centre; McMaster University; Queen's University; University of British Columbia; Centre for Addiction and Mental Health; University of Guelph; University of Calgary; University Health Network; University of Toronto","funders":"Janssen Canada; H. Lundbeck A/S; Pfizer Canada; Michael Smith Health Research BC; Mitacs; Eisai; Allergan; Canadian Network for Mood and Anxiety Treatments; Canadian Institutes of Health Research; Sunovion; Servier; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; Pfizer; Government of Ontario; Bristol-Myers Squibb","keywords":"Antidepressant; Single-nucleotide polymorphism; Meta-analysis; Major depressive disorder; Odds ratio; Medicine; Internal medicine; Tolerability; Oncology; Confidence interval; Genotyping; Pharmacogenetics; Pharmacology; Bioinformatics; Psychiatry; Genotype; Genetics; Biology; Gene; Adverse effect","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007412024,0.001867994,0.0118332,0.00398325,0.0006853692,0.002483027,0.001281515,0.001779101,0.003522486],"category_scores_gemma":[0.01975394,0.001001352,0.02597405,0.008649193,0.0005287311,0.001029971,0.001147373,0.001508824,0.0003720362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00194563,"about_ca_system_score_gemma":0.003472538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01248448,"about_ca_topic_score_gemma":0.0276725,"domain_scores_codex":[0.9937878,0.002659537,0.00181487,0.0007695983,0.0006970959,0.0002712873],"domain_scores_gemma":[0.9880135,0.008623332,0.001750694,0.0003841956,0.001066318,0.0001619899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002026517,0.00002757685,0.01190688,0.3484785,0.6188076,0.0002578179,0.0001073572,0.0006357895,0.0005193098,0.000181167,0.00209965,0.01495191],"study_design_scores_gemma":[0.0005091275,0.00009786332,0.007440137,0.01731508,0.9718069,0.0001294382,0.0000367606,0.000187952,0.0001201659,0.0001806775,0.002154501,0.00002143675],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007260531,0.9896402,0.0004481369,0.000376184,0.0001264939,0.0001916615,0.001564556,0.00002388068,0.000368317],"genre_scores_gemma":[0.255865,0.7345558,0.002617461,0.002000296,0.0003747126,0.001005945,0.002958745,0.00005057828,0.0005713493],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01248448,"threshold_uncertainty_score":0.03919905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3281714714687776,"score_gpt":0.4800795561691877,"score_spread":0.1519080847004101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}