{"id":"W4317708656","doi":"10.1053/j.gastro.2023.01.014","title":"Repurposing UDCA, an FXR Inhibitor, to Prevent SARS-Cov-2 Infection","year":2023,"lang":"en","type":"letter","venue":"Gastroenterology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"Banting and Best Diabetes Centre, University of Toronto","keywords":"Farnesoid X receptor; Ursodeoxycholic acid; Chenodeoxycholic acid; Bile acid; Angiotensin-converting enzyme 2; Lithocholic acid; Viral replication; Coronavirus; Calcitriol receptor; Receptor; Biology; Virology; Pharmacology; Medicine; Internal medicine; Endocrinology; Transcription factor; Nuclear receptor; Coronavirus disease 2019 (COVID-19); Biochemistry; Infectious disease (medical specialty); Virus; Disease; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001240153,0.0004807734,0.0007979753,0.0003960174,0.001593578,0.001548101,0.0007224535,0.02741938,0.003584973],"category_scores_gemma":[0.007381353,0.0003112499,0.0009906099,0.0002533689,0.001140195,0.001117769,0.0006040519,0.0124972,0.002678894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00271102,"about_ca_system_score_gemma":0.002303042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005219527,"about_ca_topic_score_gemma":0.009330301,"domain_scores_codex":[0.9991989,0.0002552706,0.0001052251,0.00006586443,0.0002084128,0.0001663802],"domain_scores_gemma":[0.9983936,0.0008398223,0.0001172184,0.00005342292,0.000239931,0.0003559184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003732435,0.0002129982,0.002928693,0.0001234275,0.00005672034,0.01501793,0.0001912937,0.0003094344,0.001793102,0.007155389,0.9298017,0.04203608],"study_design_scores_gemma":[0.0007951373,0.0005418585,0.005113129,0.0005585813,0.00008596462,0.01007777,0.0004251694,0.002026637,0.001745686,0.01470015,0.9638552,0.00007487092],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.003857254,0.003570124,0.0002964987,0.964927,0.01164274,0.00004264842,0.00009035321,0.00006175731,0.01551163],"genre_scores_gemma":[0.03205018,0.003126718,0.0008069724,0.9089839,0.03690762,0.00005285466,0.00009169337,0.00002787009,0.01795217],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02741938,"threshold_uncertainty_score":0.01966989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05212747071827587,"score_gpt":0.3570634067896069,"score_spread":0.304935936071331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}