{"id":"W4317721588","doi":"10.3390/molecules28031095","title":"eEF2K Inhibitor Design: The Progression of Exemplary Structure-Based Drug Design","year":2023,"lang":"en","type":"review","venue":"Molecules","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Drug discovery; Drug; Computational biology; Homology modeling; Kinase; Computer science; Pharmacology; Medicine; Bioinformatics; Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001198161,0.001121694,0.001981568,0.00203657,0.0002473411,0.001428901,0.00158324,0.001388709,0.002183415],"category_scores_gemma":[0.001384372,0.0005115538,0.0009278715,0.001600685,0.0006823273,0.001671917,0.0007725761,0.003084101,0.001326879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00103805,"about_ca_system_score_gemma":0.001032168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009620796,"about_ca_topic_score_gemma":0.001080583,"domain_scores_codex":[0.9996251,0.00007588995,0.0000411339,0.00007168251,0.0001469714,0.00003932072],"domain_scores_gemma":[0.999523,0.0002446748,0.00005358383,0.00002000827,0.0001233844,0.00003523509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001546518,0.0002289048,0.0001539642,0.01544278,0.0002370239,0.0002939664,0.00008383126,0.004108306,0.004555467,0.01966748,0.01906164,0.936012],"study_design_scores_gemma":[0.0001649878,0.0005237803,0.0003448775,0.003071926,0.0002480913,0.001014427,0.00006181256,0.002042683,0.004378291,0.01077434,0.9773256,0.0000492357],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006275365,0.9919106,0.004114599,0.0008250866,0.0002870612,0.00004512191,0.00006279044,0.00006283369,0.002064272],"genre_scores_gemma":[0.003813836,0.9896246,0.004626192,0.0005670594,0.0001965826,0.00006115522,0.0001417217,0.00001275916,0.0009561916],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002183415,"threshold_uncertainty_score":0.007531583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09679362316380691,"score_gpt":0.3743439257432832,"score_spread":0.2775503025794763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}