{"id":"W4317721991","doi":"10.1186/s40478-022-01488-4","title":"Parkin coregulates glutathione metabolism in adult mammalian brain","year":2023,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Calgary; Ottawa Hospital; University of Ottawa","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institutes of Health; Michael J. Fox Foundation for Parkinson's Research","keywords":"Parkin; Metabolism; Glutathione; Neurology; Neuroscience; Chemistry; Cell biology; Biology; Biochemistry; Parkinson's disease; Medicine; Internal medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004042036,0.0001969968,0.0002188038,0.0001365774,0.0002031245,0.00003162862,0.001084768,0.0001559082,0.00001769344],"category_scores_gemma":[0.0006655189,0.0001819487,0.0001024374,0.0005564076,0.0002366124,0.000009581762,0.0009210391,0.0002507426,0.00008622003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006172809,"about_ca_system_score_gemma":0.00003369772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002296623,"about_ca_topic_score_gemma":0.00008459297,"domain_scores_codex":[0.9983321,0.0004554976,0.0003278925,0.0003930356,0.0001186806,0.0003727645],"domain_scores_gemma":[0.9977462,0.00009168332,0.0001100598,0.001878027,0.00008595367,0.00008801899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00002924184,0.0001453862,0.002190687,0.000006299421,0.00001300261,0.00003308271,0.0002245861,0.00003936287,0.9808893,0.004723683,0.007767511,0.003937843],"study_design_scores_gemma":[0.0008348374,0.0001158569,0.5176085,0.00001380355,0.0000326693,0.00008835376,0.0002642667,0.0003806061,0.01914415,0.0006703543,0.4604092,0.0004374026],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859251,0.0009518812,0.00004613924,0.009704244,0.0001491816,0.0002552264,0.00004912492,0.0001120629,0.002806974],"genre_scores_gemma":[0.9908427,0.004048323,0.001228177,0.001938206,0.00008244399,0.0001176941,0.0004575934,0.00003466072,0.001250195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9617451,"threshold_uncertainty_score":0.7419653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02328874860456319,"score_gpt":0.2767857825271381,"score_spread":0.2534970339225749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}