{"id":"W4317739168","doi":"10.1186/s12888-022-04509-7","title":"AI-based dimensional neuroimaging system for characterizing heterogeneity in brain structure and function in major depressive disorder: COORDINATE-MDD consortium design and rationale","year":2023,"lang":"en","type":"article","venue":"BMC Psychiatry","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; McMaster University; University of Calgary; St. Joseph’s Healthcare Hamilton; Baycrest Hospital","funders":"Department of Radiology and Biomedical Imaging, University of California, San Francisco; National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; National Institute on Aging; Cumming School of Medicine, University of Calgary; School of Medicine, Emory University; Victoria General Hospital Foundation; Fok Ying Tung Education Foundation; Southwest University; Natural Science Foundation of Chongqing; University of Toronto; National Natural Science Foundation of China; Lister Institute of Preventive Medicine; Fundamental Research Funds for the Central Universities; National Institutes of Health; H. Lundbeck A/S; Rosetrees Trust; University of Oxford; Laureate Institute for Brain Research, University of Tulsa; Michael Smith Health Research BC; Sage Therapeutics; King's College London; Neurocrine Biosciences; Wellcome Trust; Zogenix; Canadian Institutes of Health Research; Otsuka Canada Pharmaceutical; Hersh Foundation; American Foundation for Suicide Prevention; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Sunovion; Fondation Brain Canada; LivaNova; Patient-Centered Outcomes Research Institute; Medical Research Council; Servier; William K. Warren Foundation; Biogen; Pfizer; Ontario Brain Institute; NIHR Maudsley Biomedical Research Centre; National Institute on Drug Abuse; South London and Maudsley NHS Foundation Trust; National Institute for Health and Care Research; Massachusetts General Hospital; Sackler Trust; Emory University; Otsuka Pharmaceutical; National Institute of General Medical Sciences; National Alliance for Research on Schizophrenia and Depression; Lundbeckfonden; Eli Lilly and Company; University of Pennsylvania","keywords":"Neuroimaging; Major depressive disorder; Psychology; Brain function; Function (biology); Brain Structure and Function; Neuroscience; Psychiatry; Medicine; Cognition; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05529865,0.001294627,0.001140823,0.003138675,0.00256282,0.002606846,0.003124756,0.001350643,0.003836766],"category_scores_gemma":[0.0500161,0.0008108984,0.001965176,0.004264047,0.003103222,0.001202184,0.006651968,0.001665191,0.0009075938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002449976,"about_ca_system_score_gemma":0.006740554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008240064,"about_ca_topic_score_gemma":0.006178667,"domain_scores_codex":[0.9516066,0.03844853,0.00214522,0.003787345,0.003005566,0.001006679],"domain_scores_gemma":[0.9612095,0.008786622,0.005376976,0.01162863,0.01005724,0.002940993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0127878,0.002417637,0.6126737,0.001846702,0.004569298,0.001343589,0.005769973,0.03155337,0.008872395,0.1180947,0.03415587,0.1659152],"study_design_scores_gemma":[0.0101471,0.01312103,0.4665946,0.0009177484,0.004213394,0.003587647,0.005274825,0.1837911,0.01571266,0.1249648,0.1707586,0.0009164829],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"protocol","genre_scores_codex":[0.2937093,0.0009917398,0.5849718,0.002710193,0.0003842458,0.08327997,0.02436695,0.001250233,0.008335512],"genre_scores_gemma":[0.3775233,0.0002814622,0.4030088,0.0006732212,0.0001631906,0.2037143,0.01303739,0.0001737571,0.001424607],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.05529865,"threshold_uncertainty_score":0.2924507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02988997390697049,"score_gpt":0.2668397817120656,"score_spread":0.2369498078050951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}