{"id":"W4317739168","doi":"10.1186/s12888-022-04509-7","title":"AI-based dimensional neuroimaging system for characterizing heterogeneity in brain structure and function in major depressive disorder: COORDINATE-MDD consortium design and rationale","year":2023,"lang":"en","type":"article","venue":"BMC Psychiatry","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; McMaster University; University of Calgary; St. Joseph’s Healthcare Hamilton; Baycrest Hospital","funders":"Department of Radiology and Biomedical Imaging, University of California, San Francisco; National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; National Institute on Aging; Cumming School of Medicine, University of Calgary; School of Medicine, Emory University; Victoria General Hospital Foundation; Fok Ying Tung Education Foundation; Southwest University; Natural Science Foundation of Chongqing; University of Toronto; National Natural Science Foundation of China; Lister Institute of Preventive Medicine; Fundamental Research Funds for the Central Universities; National Institutes of Health; H. Lundbeck A/S; Rosetrees Trust; University of Oxford; Laureate Institute for Brain Research, University of Tulsa; Michael Smith Health Research BC; Sage Therapeutics; King's College London; Neurocrine Biosciences; Wellcome Trust; Zogenix; Canadian Institutes of Health Research; Otsuka Canada Pharmaceutical; Hersh Foundation; American Foundation for Suicide Prevention; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Sunovion; Fondation Brain Canada; LivaNova; Patient-Centered Outcomes Research Institute; Medical Research Council; Servier; William K. Warren Foundation; Biogen; Pfizer; Ontario Brain Institute; NIHR Maudsley Biomedical Research Centre; National Institute on Drug Abuse; South London and Maudsley NHS Foundation Trust; National Institute for Health and Care Research; Massachusetts General Hospital; Sackler Trust; Emory University; Otsuka Pharmaceutical; National Institute of General Medical Sciences; National Alliance for Research on Schizophrenia and Depression; Lundbeckfonden; Eli Lilly and Company; University of Pennsylvania","keywords":"Neuroimaging; Major depressive disorder; Psychology; Brain function; Function (biology); Brain Structure and Function; Neuroscience; Psychiatry; Medicine; Cognition; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003346541,0.0002014768,0.0002333177,0.0002915218,0.0003123739,0.00006777109,0.00007174972,0.00006983116,0.000002370146],"category_scores_gemma":[0.001233191,0.00020308,0.00004004476,0.000395553,0.00009714421,0.0002525522,0.00007555309,0.0001710849,0.00000185685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004535214,"about_ca_system_score_gemma":0.0001195155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002031691,"about_ca_topic_score_gemma":0.0003976131,"domain_scores_codex":[0.9982316,0.0003068457,0.0002758907,0.0007092872,0.000190053,0.0002862907],"domain_scores_gemma":[0.9966881,0.002963176,0.0001166702,0.0001451235,0.00003573573,0.00005125008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008652462,0.00006077219,0.8816905,0.0004337199,0.000009272969,0.000004013439,0.00005879328,0.007082128,0.1071388,0.001334261,0.001045556,0.0002769618],"study_design_scores_gemma":[0.004231167,0.0001404219,0.8712692,0.0001539456,0.00001795227,0.00003568153,0.0001216604,0.1123674,0.008544936,0.002563589,0.0002326364,0.0003214487],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825384,0.0001910136,0.005898383,0.009059855,0.001063159,0.001044572,0.00009462477,0.0001062182,0.000003753963],"genre_scores_gemma":[0.995074,0.000002385861,0.0007821416,0.003796373,0.00007712823,0.0002066076,0.00002055059,0.00002721196,0.00001360616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1052852,"threshold_uncertainty_score":0.828136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02988997390697049,"score_gpt":0.2668397817120656,"score_spread":0.2369498078050951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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