{"id":"W4317751876","doi":"10.1186/s13578-023-00966-z","title":"Identification of the molecular mechanism of insulin-like growth factor-1 (IGF-1): a promising therapeutic target for neurodegenerative diseases associated with metabolic syndrome","year":2023,"lang":"en","type":"review","venue":"Cell & Bioscience","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Research Foundation of Korea; Chonnam National University; National Research Foundation; Chonnam National University Hwasun Hospital; Mike and Josie Harper Cancer Research Institute","keywords":"Neurodegeneration; Metabolic syndrome; Medicine; Bioinformatics; Neurogenesis; Huntington's disease; Disease; Cognitive decline; Neuroscience; Biology; Diabetes mellitus; Internal medicine; Endocrinology; Dementia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000331145,0.0006853,0.0008296235,0.001494756,0.0002113265,0.0007197229,0.0005121803,0.0008692875,0.002861282],"category_scores_gemma":[0.000384637,0.0001617542,0.0004037815,0.001167194,0.000318352,0.0009022803,0.0004763858,0.001690943,0.001190069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004339915,"about_ca_system_score_gemma":0.0007721301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007462124,"about_ca_topic_score_gemma":0.00133402,"domain_scores_codex":[0.9999102,0.00001468585,0.00001263551,0.0000169037,0.00003479864,0.00001072798],"domain_scores_gemma":[0.9998761,0.0000511525,0.00001681217,0.000003930964,0.00003927216,0.00001278555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001426034,0.00009702527,0.0002468446,0.01669145,0.0001282516,0.0003401777,0.00006059221,0.0003570331,0.005925857,0.005974859,0.02698716,0.9430481],"study_design_scores_gemma":[0.00003477446,0.0001745151,0.001057833,0.002973611,0.000182707,0.001830988,0.00006960961,0.0001839704,0.001927536,0.002782189,0.988758,0.00002424012],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001612645,0.9983078,0.0001620645,0.0003015206,0.000229541,0.000003784419,0.00001639602,0.000005959811,0.000811589],"genre_scores_gemma":[0.001081106,0.9976751,0.0002592695,0.0002095891,0.0001513545,0.000007202541,0.00002972915,0.000001275482,0.0005852962],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002861282,"threshold_uncertainty_score":0.00957197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03791747422555943,"score_gpt":0.2864633406932346,"score_spread":0.2485458664676752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}