{"id":"W4317778069","doi":"10.1016/j.isci.2023.105975","title":"The Staphylococcus aureus protein IsdA increases SARS CoV-2 replication by modulating JAK-STAT signaling","year":2023,"lang":"en","type":"article","venue":"iScience","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Schulich School of Medicine and Dentistry; Canadian Institutes of Health Research; British Society for Antimicrobial Chemotherapy","keywords":"Staphylococcus aureus; STAT protein; stat; Janus kinase; Viral replication; STAT3; Biology; JAK-STAT signaling pathway; Signal transduction; Microbiology; Cell biology; Virology; Virus; Bacteria; Genetics; Tyrosine kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001053795,0.000221861,0.0001853687,0.0001366445,0.0001387714,0.0003318631,0.00008606571,0.0002345501,0.001708143],"category_scores_gemma":[0.0000962206,0.00008396969,0.0002262908,0.00006811416,0.0001793533,0.0001307603,0.0001806296,0.0004860174,0.0003223526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002629321,"about_ca_system_score_gemma":0.0002020244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003406433,"about_ca_topic_score_gemma":0.0006637264,"domain_scores_codex":[0.9998273,0.00003801932,0.00001280606,0.00002685847,0.00004768023,0.00004735242],"domain_scores_gemma":[0.9999183,0.00001248232,0.00002357689,0.000007385992,0.000009895924,0.00002828142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001511879,0.00005206253,0.0003285113,0.00002219642,0.000003287407,0.00002590551,0.000006591542,0.00003062519,0.9986759,0.00003777554,0.00004730529,0.0006186494],"study_design_scores_gemma":[0.00003863278,0.001281779,0.02235066,0.00001982693,0.00002096855,0.0003547932,0.0001014233,0.001886659,0.9707605,0.0001038047,0.003074086,0.000006937284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955457,0.001410234,0.0007731206,0.0001693307,0.00007037306,0.00001355245,0.0001981584,0.00003318208,0.001786341],"genre_scores_gemma":[0.997339,0.0004412917,0.0006883738,0.0000611655,0.00001273923,0.00001065192,0.000163959,0.000005523584,0.001277368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001708143,"threshold_uncertainty_score":0.005714357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05578837594346975,"score_gpt":0.3680729300877752,"score_spread":0.3122845541443054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}