{"id":"W4317810050","doi":"10.1016/j.celrep.2023.112021","title":"Epiblast-like stem cells established by Wnt/β-catenin signaling manifest distinct features of formative pluripotency and germline competence","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of General Medical Sciences; Medical Research Council; China Scholarship Council; National Institutes of Health; Vetenskapsrådet; Welch Foundation; Knut och Alice Wallenbergs Stiftelse; Medicinska Forskningsrådet; Karolinska Institutet; Åke Wiberg Stiftelse; New York Stem Cell Foundation","keywords":"Epiblast; Wnt signaling pathway; Biology; Cell biology; Stem cell; Induced pluripotent stem cell; Germline; Cellular differentiation; Embryonic stem cell; Genetics; Gastrulation; Signal transduction; Embryo; Embryogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001102221,0.0002581892,0.0001346222,0.0002397796,0.0001237038,0.0002668781,0.0001146823,0.0001999071,0.001158958],"category_scores_gemma":[0.00008845192,0.0001205911,0.0001814333,0.0001212378,0.0001685868,0.0001609901,0.0001981133,0.0004267644,0.0003780676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001333986,"about_ca_system_score_gemma":0.0001202428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002343212,"about_ca_topic_score_gemma":0.0007794485,"domain_scores_codex":[0.999933,0.000006961041,0.000008996897,0.00001484239,0.00002691847,0.000009291702],"domain_scores_gemma":[0.9999094,0.00001448192,0.00002082014,0.00001406758,0.00001342425,0.00002776234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001683739,0.00000459346,0.0002897454,0.0000104129,0.000002118699,0.00005515441,0.00001608424,0.00001969277,0.9985452,0.0001718586,0.00001113306,0.0008572454],"study_design_scores_gemma":[0.000006877254,0.0001143909,0.006859265,0.000004526264,0.00001238826,0.0004798715,0.00002969709,0.0003121513,0.9882516,0.00007916016,0.003846771,0.000003413858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740393,0.001237149,0.01809251,0.00005924716,0.00003313929,0.000100104,0.000958422,0.0001621543,0.005318048],"genre_scores_gemma":[0.9806938,0.0008365193,0.007335889,0.00006576284,0.00001163278,0.00007773417,0.001948057,0.00003863513,0.008991946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001158958,"threshold_uncertainty_score":0.003877103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009321196601364969,"score_gpt":0.2361624000544824,"score_spread":0.2268412034531174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}