{"id":"W4317811105","doi":"10.3390/cancers15030671","title":"IL-15 Prevents the Development of T-ALL from Aberrant Thymocytes with Impaired DNA Repair Functions and Increased NOTCH1 Activation","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; Université de Sherbrooke","funders":"Faculty of Medicine and Health, University of Sydney; Fonds de Recherche du Québec - Santé; Université de Sherbrooke; Cancer Research Society","keywords":"Thymocyte; CD8; Double negative; Nod; T-cell receptor; Biology; NOD mice; Molecular biology; Cytotoxic T cell; Immunology; T cell; Cancer research; Cell biology; Endocrinology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001716115,0.0003959039,0.0003564723,0.0003685194,0.000121984,0.0003358959,0.0003158167,0.0002549175,0.001324132],"category_scores_gemma":[0.0001342072,0.0001857904,0.0003344112,0.0001665079,0.0002068707,0.0001880302,0.0002444721,0.0007437809,0.0003608581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002154906,"about_ca_system_score_gemma":0.0002762169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004455801,"about_ca_topic_score_gemma":0.0009575498,"domain_scores_codex":[0.9997495,0.00003649787,0.00004799165,0.00004083655,0.00006271989,0.00006252161],"domain_scores_gemma":[0.9997184,0.00002648451,0.000097352,0.00002886529,0.00001673168,0.0001122075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002868764,0.0000990237,0.0003266092,0.00004256086,0.000009674131,0.00006621549,0.00001363981,0.00005563872,0.9977963,0.0000632693,0.00003350643,0.001206794],"study_design_scores_gemma":[0.0000888693,0.001232437,0.005757907,0.00001855803,0.00003571417,0.0005500474,0.00003333254,0.0006976785,0.9886255,0.00004925553,0.002905337,0.000005341844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959937,0.001285197,0.0009812635,0.00006576758,0.00003521309,0.00003869748,0.0004835792,0.000108514,0.001008007],"genre_scores_gemma":[0.9936246,0.0007166824,0.001660009,0.00007424421,0.00001577119,0.00005361618,0.001096546,0.00002596861,0.002732618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001324132,"threshold_uncertainty_score":0.004429698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01824634224408388,"score_gpt":0.2322349080097398,"score_spread":0.2139885657656559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}