{"id":"W4317830464","doi":"10.1002/cac2.12401","title":"A nanotherapeutic strategy to target drug‐tolerant cells and overcome EGFR tyrosine kinase inhibitor resistance in lung cancer","year":2023,"lang":"en","type":"letter","venue":"Cancer Communications","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; FujiFilm VisualSonics (Canada)","funders":"National Cancer Institute; National Institutes of Health","keywords":"Cancer research; Epidermal growth factor receptor; Lung cancer; Population; Receptor tyrosine kinase; Drug resistance; AXL receptor tyrosine kinase; Medicine; Cancer; Chemistry; Pharmacology; Biology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003406675,0.0003541159,0.0009682797,0.0004342744,0.0002308433,0.0000598808,0.0006777869,0.0004466899,0.0003470953],"category_scores_gemma":[0.00005288811,0.0003381572,0.00009291467,0.0008006881,0.0004092072,0.00006795357,0.0003413549,0.001997158,0.00004730762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001174197,"about_ca_system_score_gemma":0.001523652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003766957,"about_ca_topic_score_gemma":0.009685245,"domain_scores_codex":[0.9975377,0.0003265883,0.0005862056,0.0005317214,0.0003889659,0.0006287749],"domain_scores_gemma":[0.9968028,0.0006883088,0.0001601562,0.001929991,0.0002296592,0.0001890629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001742749,0.000136829,0.01290364,0.001271646,0.0002926085,0.0002316939,0.001645525,0.00002182431,0.002163749,0.0001239652,0.9803194,0.0007148489],"study_design_scores_gemma":[0.001816896,0.00009355383,0.0139261,0.003266949,0.0003614525,0.000006915797,0.0001273816,0.001016726,0.0001334795,0.000232555,0.9785615,0.0004564996],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02126772,0.07661872,0.0000324357,0.8950556,0.0003471112,0.00235993,0.000957247,0.000116033,0.003245207],"genre_scores_gemma":[0.07081818,0.0991107,0.007917574,0.6311876,0.003317503,0.01241546,0.00115879,0.0005139682,0.1735602],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.263868,"threshold_uncertainty_score":0.999907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06163173093804817,"score_gpt":0.387045254619975,"score_spread":0.3254135236819268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}