{"id":"W4317840197","doi":"10.32920/21948443.v1","title":"Proximity Profiling of the CFTR Interaction Landscape in Response to Orkambi","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Metropolitan University","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; Cystic Fibrosis Foundation","keywords":"Cystic fibrosis transmembrane conductance regulator; Interactome; Chloride channel; Cystic fibrosis; Efflux; ΔF508; Biology; Regulator; Cell biology; Computational biology; Chemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009116289,0.0001467783,0.0002623171,0.000256088,0.0002317463,0.0002788547,0.0001452308,0.0002275299,0.0009258973],"category_scores_gemma":[0.0001893585,0.0001378911,0.0001627512,0.0002279907,0.0001389531,0.0001379273,0.0003135492,0.0003604881,0.0003391538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001967397,"about_ca_system_score_gemma":0.0001148276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001522667,"about_ca_topic_score_gemma":0.002469328,"domain_scores_codex":[0.9998507,0.00001885865,0.000006433293,0.00003843381,0.0000482514,0.00003721848],"domain_scores_gemma":[0.9999174,0.00002035411,0.00002205308,0.000008632192,0.00001292802,0.00001865173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001116333,0.00000615042,0.0004573857,0.00002914623,0.000005424187,0.00002806098,0.00002040771,0.0000584079,0.9983734,0.00002357139,0.00003662383,0.0008498061],"study_design_scores_gemma":[0.00002132148,0.0002283531,0.08702046,0.00001396509,0.00003294017,0.0004284688,0.0001820697,0.004532482,0.9046742,0.00009967599,0.002749745,0.00001629952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947989,0.001016743,0.002497605,0.0000884972,0.000007536903,0.00001890972,0.0008570951,0.00005687013,0.0006577974],"genre_scores_gemma":[0.9919696,0.0007235562,0.004040214,0.00007830558,0.000004114631,0.00004443848,0.001448315,0.00003489374,0.001656484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001522667,"threshold_uncertainty_score":0.003097415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02311229906002254,"score_gpt":0.2949353616430338,"score_spread":0.2718230625830113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}