{"id":"W4317840197","doi":"10.32920/21948443.v1","title":"Proximity Profiling of the CFTR Interaction Landscape in Response to Orkambi","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Metropolitan University","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; Cystic Fibrosis Foundation","keywords":"Cystic fibrosis transmembrane conductance regulator; Interactome; Chloride channel; Cystic fibrosis; Efflux; ΔF508; Biology; Regulator; Cell biology; Computational biology; Chemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003994188,0.000127324,0.0001546676,0.00006106339,0.00003169711,0.000009242774,0.0002025451,0.0003540898,0.000005127165],"category_scores_gemma":[0.0003025271,0.00008138415,0.0001010723,0.0001195882,0.00003133409,6.675925e-7,0.001100689,0.0003426452,0.000007425613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000143466,"about_ca_system_score_gemma":0.00008121976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005983159,"about_ca_topic_score_gemma":0.0002479387,"domain_scores_codex":[0.9991063,0.0001376451,0.0002282432,0.0003100639,0.00008868466,0.0001290473],"domain_scores_gemma":[0.99944,0.00002141916,0.00008894574,0.0003639442,0.00006369494,0.00002202683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00222935,0.0001611488,0.04238126,0.0002899385,0.0002665321,0.000004284621,0.0005167981,0.002838627,0.9421338,0.00004133618,0.007730318,0.001406628],"study_design_scores_gemma":[0.0004965764,0.0001972003,0.07946337,0.0004658456,0.00003504732,0.000004610626,0.000987337,0.0002954678,0.911332,0.0001770918,0.006195342,0.0003500768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950117,0.0002082107,0.0001075283,0.001935623,0.0007867999,0.0005068202,0.00001632315,0.00001644508,0.001410531],"genre_scores_gemma":[0.9945792,0.0001388592,0.0006652309,0.00009586772,0.00007185868,0.00004242369,0.00002426925,0.00001619349,0.004366074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03708211,"threshold_uncertainty_score":0.3318749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02311229906002254,"score_gpt":0.2949353616430338,"score_spread":0.2718230625830113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}