{"id":"W4317851266","doi":"10.1073/pnas.2213777120","title":"Activation of the NLRP1 inflammasome in human keratinocytes by the dsDNA mimetic poly(dA:dT)","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institutes of Health; Ottawa Hospital Research Institute","keywords":"Inflammasome; AIM2; Caspase 1; Cell biology; Pyroptosis; Programmed cell death; NLRP1; Chemistry; Caspase; Biology; Apoptosis; Molecular biology; Biochemistry; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001786983,0.0002217732,0.0001678236,0.000133671,0.0001843931,0.0003225275,0.0001014712,0.0003020249,0.001907178],"category_scores_gemma":[0.0001000476,0.0001458545,0.0002623453,0.0001896613,0.0001226167,0.0002193477,0.000142551,0.0004529322,0.0008817036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001618195,"about_ca_system_score_gemma":0.0001516058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003294739,"about_ca_topic_score_gemma":0.0004147737,"domain_scores_codex":[0.9997398,0.00004814002,0.00003989452,0.00006210817,0.00007183953,0.00003808215],"domain_scores_gemma":[0.9999398,0.00001259867,0.00001133572,0.00001728529,0.000008624684,0.00001038207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001300824,0.00004488171,0.0002025835,0.00005899297,0.00000483952,0.00008435932,0.00002350166,0.00004063329,0.9980566,0.00003527519,0.0000448131,0.001273397],"study_design_scores_gemma":[0.00002452466,0.0006539641,0.005464791,0.00000729985,0.00001750674,0.0007222074,0.00004738012,0.0004708847,0.9894021,0.00004333017,0.003141239,0.000004822123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98206,0.005576441,0.006727886,0.000160544,0.0001479707,0.0001531223,0.001118865,0.0001138402,0.003941309],"genre_scores_gemma":[0.9890998,0.002002717,0.003574276,0.00009235543,0.00001951514,0.0001154107,0.001093273,0.00001018115,0.003992305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001907178,"threshold_uncertainty_score":0.006380141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02260088575280188,"score_gpt":0.2890672997320707,"score_spread":0.2664664139792688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}