{"id":"W4317862749","doi":"10.1200/jco.2023.41.4_suppl.291","title":"Nivolumab (NIVO) plus chemotherapy (chemo) vs chemo as first-line (1L) treatment for advanced gastric cancer/gastroesophageal junction cancer/esophageal adenocarcinoma (GC/GEJC/EAC): 3-year follow-up from CheckMate 649.","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Nivolumab; Internal medicine; Oncology; FOLFOX; Ipilimumab; Cancer; Gastroesophageal Junction; Randomized controlled trial; Adenocarcinoma; Immunotherapy; Oxaliplatin; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001484763,0.000639732,0.001306515,0.0003413191,0.0002855016,0.0006660799,0.0007024914,0.0008811615,0.002813597],"category_scores_gemma":[0.0009255682,0.0003027658,0.001331075,0.0003134616,0.0005879864,0.0005357604,0.0003876272,0.001426117,0.0003793376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00121033,"about_ca_system_score_gemma":0.00104363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00116756,"about_ca_topic_score_gemma":0.003267907,"domain_scores_codex":[0.9994876,0.0002422796,0.00003734427,0.00008757716,0.00004227945,0.0001028364],"domain_scores_gemma":[0.9992833,0.0001545734,0.000223317,0.00005059881,0.00002935834,0.0002588801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.947646,0.01256092,0.005013271,0.0003764917,0.0008832226,0.00005232559,0.00005923287,0.0008764061,0.004742187,0.00006808317,0.0005973779,0.02712457],"study_design_scores_gemma":[0.3761337,0.5805928,0.03259411,0.00007435914,0.002130575,0.0001265462,0.00005754913,0.001765088,0.004179672,0.0001867069,0.002125891,0.00003303048],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961239,0.001159611,0.0001248819,0.0001004354,0.00007439874,0.001010353,0.0006204482,0.00002329044,0.0007626358],"genre_scores_gemma":[0.9967839,0.0005249829,0.0003018425,0.0002182891,0.00007505342,0.0007187582,0.0005829297,0.000005901736,0.0007883151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002813597,"threshold_uncertainty_score":0.009412467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08883121524277672,"score_gpt":0.4229260085238555,"score_spread":0.3340947932810788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}