{"id":"W4317862760","doi":"10.1200/jco.2023.41.4_suppl.7","title":"Long-term results from NRG-GI002: A phase II clinical trial platform using total neoadjuvant therapy (TNT) in locally advanced rectal cancer (LARC).","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Surgical Treatments","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Institutes of Health","keywords":"Medicine; Clinical endpoint; Colorectal cancer; Randomized controlled trial; FOLFOX; Capecitabine; Internal medicine; Total mesorectal excision; Phases of clinical research; Surgery; Gastroenterology; Cancer; Clinical trial; Oxaliplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002724384,0.001239125,0.001009772,0.0003026974,0.0003262096,0.0008458243,0.0008022322,0.001192024,0.005063819],"category_scores_gemma":[0.001401737,0.0003296052,0.001323436,0.0003766513,0.0007900546,0.0007435697,0.0005928167,0.002516821,0.00100304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007703967,"about_ca_system_score_gemma":0.001885307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005619378,"about_ca_topic_score_gemma":0.002850526,"domain_scores_codex":[0.9994072,0.0003503362,0.00002340178,0.00007341024,0.00005690019,0.00008883858],"domain_scores_gemma":[0.9992394,0.0001171158,0.000178333,0.00007746836,0.000047469,0.0003401062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8220391,0.05088847,0.004865213,0.001392507,0.001355733,0.0001633542,0.0002066196,0.002565114,0.02361451,0.000497279,0.01075541,0.08165674],"study_design_scores_gemma":[0.5378833,0.4474824,0.00773563,0.00007473225,0.000465214,0.0001883009,0.00005103232,0.0008676517,0.001781071,0.0003062708,0.003134025,0.00003033339],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843274,0.00209153,0.0009259884,0.00110374,0.0002149983,0.004528937,0.003099832,0.0002019483,0.003505709],"genre_scores_gemma":[0.9707823,0.001866191,0.003803694,0.00197988,0.0002376901,0.01001787,0.006767422,0.00007624328,0.004468672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005063819,"threshold_uncertainty_score":0.01694018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3593571677945596,"score_gpt":0.5727178297137407,"score_spread":0.2133606619191812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}