{"id":"W4317867047","doi":"10.1016/j.molmet.2023.101678","title":"Sex differences in islet stress responses support female β cell resilience","year":2023,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Breakthrough T1D Canada; Canadian Institutes of Health Research; University of British Columbia; Genome British Columbia; Canada Foundation for Innovation; Diabetes Canada; Michael Smith Health Research BC; University of Victoria; Canadian Diabetes Association","keywords":"Islet; Unfolded protein response; Biology; Endocrinology; Internal medicine; Transcriptome; Type 2 diabetes; Glucose homeostasis; Insulin; Gene expression; Pancreatic islets; Endoplasmic reticulum; Diabetes mellitus; Gene; Insulin resistance; Cell biology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003314982,0.0001614334,0.0004080745,0.0003432564,0.0000439652,0.00002422157,0.0001200538,0.00006960207,0.0003397841],"category_scores_gemma":[0.000386715,0.000136491,0.00008880542,0.000679191,0.00007911588,0.00005095165,0.00006006756,0.0001581696,0.0003489545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001406213,"about_ca_system_score_gemma":0.0001109912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006030304,"about_ca_topic_score_gemma":0.000002490976,"domain_scores_codex":[0.9985135,0.0001499941,0.0002535286,0.0003365165,0.0003809623,0.0003654978],"domain_scores_gemma":[0.9992558,0.0001271639,0.00004979733,0.0003797061,0.00004243381,0.000145062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002863599,0.0002994659,0.247106,0.0001817616,0.00005453689,0.001386698,0.001348228,0.00003955471,0.7427118,0.0006814536,0.003684728,0.00221937],"study_design_scores_gemma":[0.001540372,0.00008560136,0.4887666,0.0000563873,0.0000819185,0.000008909597,0.0008137315,0.0002773012,0.5001649,0.0001954044,0.007800732,0.0002081019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876212,0.0008110414,0.00009080954,0.0004547187,0.0002102573,0.0002144466,0.00002323033,0.0001304693,0.01044385],"genre_scores_gemma":[0.9824252,0.0001418386,0.0002565834,0.0008373397,0.00005955302,0.00004468586,0.00003733914,0.00002021277,0.0161773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2425469,"threshold_uncertainty_score":0.5565941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01876303512423322,"score_gpt":0.2678114912429816,"score_spread":0.2490484561187484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}