{"id":"W4317867047","doi":"10.1016/j.molmet.2023.101678","title":"Sex differences in islet stress responses support female β cell resilience","year":2023,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Breakthrough T1D Canada; Canadian Institutes of Health Research; University of British Columbia; Genome British Columbia; Canada Foundation for Innovation; Diabetes Canada; Michael Smith Health Research BC; University of Victoria; Canadian Diabetes Association","keywords":"Islet; Unfolded protein response; Biology; Endocrinology; Internal medicine; Transcriptome; Type 2 diabetes; Glucose homeostasis; Insulin; Gene expression; Pancreatic islets; Endoplasmic reticulum; Diabetes mellitus; Gene; Insulin resistance; Cell biology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006641779,0.0003778009,0.0004276543,0.0005658783,0.0003824811,0.0008088624,0.0002430947,0.0002972191,0.005098202],"category_scores_gemma":[0.0007080157,0.0001828758,0.0007156834,0.0003470755,0.0003642137,0.0003113556,0.0005753214,0.0006993202,0.0009366575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001581547,"about_ca_system_score_gemma":0.000234489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002697794,"about_ca_topic_score_gemma":0.0004570348,"domain_scores_codex":[0.999566,0.000059449,0.00003362048,0.0001881087,0.00009479678,0.00005798366],"domain_scores_gemma":[0.9993655,0.0001047246,0.0002531527,0.00009052741,0.00009571105,0.00009038791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001719932,0.00009702922,0.08498864,0.000353778,0.0002459408,0.0006494183,0.0003156825,0.0002128931,0.8840985,0.0006769492,0.001437288,0.02520393],"study_design_scores_gemma":[0.00007942038,0.0007380507,0.7703028,0.0001455706,0.0003353792,0.002907767,0.0004884712,0.000740558,0.2037405,0.001373903,0.01908368,0.00006391729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705028,0.005983936,0.009797832,0.0005653498,0.0002516092,0.00004683726,0.008399113,0.0002235798,0.00422884],"genre_scores_gemma":[0.985608,0.002230652,0.003500956,0.0006186783,0.0001376026,0.0001059878,0.004783909,0.0001700293,0.002844336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005098202,"threshold_uncertainty_score":0.01705515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01876303512423322,"score_gpt":0.2678114912429816,"score_spread":0.2490484561187484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}