{"id":"W4317876057","doi":"10.1002/ange.202212879","title":"Simultaneous Detection of L‐Lactate and D‐Glucose Using DNA Aptamers in Human Blood Serum**","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Global Water Futures; Canada First Research Excellence Fund","keywords":"Aptamer; Lactic acid; Isothermal titration calorimetry; Chemistry; Metabolite; Biochemistry; Detection limit; Biosensor; Glycolysis; Analyte; Sodium lactate; Chromatography; Molecular biology; Biology; Bacteria; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002833385,0.000437349,0.0002202512,0.0002502182,0.00009197196,0.0002772445,0.0001971666,0.0005070901,0.0005619633],"category_scores_gemma":[0.0003541525,0.0001259055,0.0001296048,0.0002446159,0.0001685349,0.0001569934,0.0001551281,0.0003009329,0.0003296407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003259556,"about_ca_system_score_gemma":0.0001388266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000446727,"about_ca_topic_score_gemma":0.0004831255,"domain_scores_codex":[0.9997259,0.00006366897,0.00001613462,0.000106806,0.00005667017,0.00003079658],"domain_scores_gemma":[0.9998529,0.00005445554,0.00002637709,0.000007235783,0.00003581585,0.00002333718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009009252,0.00001456804,0.0001934222,0.00002474175,0.000002439346,0.0000208691,0.00001669995,0.00009004003,0.997145,0.00002227976,0.00004250295,0.002337279],"study_design_scores_gemma":[0.000007395066,0.0001195393,0.000337223,0.000002273868,0.000003549437,0.00005338512,0.000008542636,0.001628674,0.997375,0.00002033132,0.000440788,0.000003358457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9283944,0.003128773,0.06497439,0.0003600055,0.0001536959,0.00009233189,0.0004867556,0.0005976899,0.001811964],"genre_scores_gemma":[0.966094,0.0006902462,0.02915697,0.0002437208,0.00002422896,0.0001101229,0.0002734356,0.00002553842,0.003381717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005619633,"threshold_uncertainty_score":0.002365053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01267595953188685,"score_gpt":0.2731797471061714,"score_spread":0.2605037875742846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}