{"id":"W4317878767","doi":"10.1101/2023.01.23.22283996","title":"Personalized Inhaled Bacteriophage Therapy Decreases Multidrug-Resistant <i>Pseudomonas aeruginosa</i>","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health; University of Pittsburgh; Texas Tech University; Yale Center for Clinical Investigation, Yale School of Medicine; Yale University","keywords":"Pseudomonas aeruginosa; Phage therapy; Bacteriophage; Lytic cycle; Antibiotic resistance; Microbiology; Sputum; Virulence; Cystic fibrosis; Antibiotics; Bacteria; Antimicrobial; Multiple drug resistance; Biology; Virology; Medicine; Virus; Escherichia coli; Tuberculosis; Internal medicine; Gene; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001696663,0.0001726927,0.0003637669,0.00007883412,0.000169886,0.0003329917,0.00009395801,0.0002902439,0.002039975],"category_scores_gemma":[0.0002775677,0.00004500707,0.0001913008,0.00004909842,0.0001525391,0.000134864,0.0002243143,0.0004443905,0.0002130185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001225232,"about_ca_system_score_gemma":0.0001276531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002538147,"about_ca_topic_score_gemma":0.000411918,"domain_scores_codex":[0.9999101,0.00001862122,0.000004451753,0.00001842384,0.00002445624,0.00002400383],"domain_scores_gemma":[0.9999067,0.00002207907,0.00002426043,0.000009574657,0.000008754533,0.00002869382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007136647,0.003464174,0.04098532,0.0003445969,0.0001509517,0.0003629467,0.0003466573,0.001503962,0.7506707,0.0002856241,0.001811753,0.1929366],"study_design_scores_gemma":[0.001322279,0.09052373,0.4673047,0.0001079684,0.000449946,0.002116126,0.000543659,0.005952903,0.4213634,0.0004367131,0.009831108,0.0000475169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974184,0.0007610402,0.0006833703,0.0001164032,0.00001812837,0.00002219371,0.00006109371,0.00004760315,0.0008718419],"genre_scores_gemma":[0.9983144,0.0002035609,0.0006379536,0.0000823648,0.00001605355,0.00001567964,0.00006288697,0.00001184349,0.0006552502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002039975,"threshold_uncertainty_score":0.006824374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03351064731241624,"score_gpt":0.2714353804263168,"score_spread":0.2379247331139005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}