{"id":"W4317881092","doi":"10.3389/fimmu.2023.1042686","title":"Phosphoinositol 3-kinase-driven NET formation involves different isoforms and signaling partners depending on the stimulus","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Insmed","keywords":"PI3K/AKT/mTOR pathway; P70-S6 Kinase 1; Protein kinase B; Cell biology; Signal transduction; Effector; Biology; Phosphoinositide 3-kinase; Phosphorylation; Kinase; Neutrophil extracellular traps; Gene isoform; Neuroscience; Inflammation; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001480166,0.0003826939,0.0001439911,0.0002723246,0.000216994,0.0004156786,0.0001297515,0.0001744046,0.001171858],"category_scores_gemma":[0.00005925707,0.0001343385,0.0003468154,0.0001853618,0.0002111392,0.0003784585,0.0002637905,0.0005741083,0.0003433874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004020481,"about_ca_system_score_gemma":0.0002318115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000241611,"about_ca_topic_score_gemma":0.000592541,"domain_scores_codex":[0.9998894,0.00001035403,0.000009362838,0.00002797377,0.00002997506,0.00003291893],"domain_scores_gemma":[0.9999505,0.00000585926,0.00001591986,0.000003830318,0.000006731643,0.00001711564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002625464,0.00002900324,0.0007809945,0.00009350458,0.000007847692,0.0001196797,0.00002136848,0.0001071549,0.9960388,0.0003595418,0.00006214614,0.002117368],"study_design_scores_gemma":[0.00003847559,0.000251604,0.03363528,0.00003176097,0.00004468843,0.0007996797,0.0001174965,0.002586845,0.9574178,0.0004836427,0.004581136,0.00001153873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876302,0.00341873,0.004831174,0.0002417185,0.00005882309,0.00004899574,0.000736825,0.00007331846,0.002960055],"genre_scores_gemma":[0.9911439,0.002543784,0.002734967,0.000087745,0.00001329163,0.00005204107,0.0006421984,0.00001199075,0.002770118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001171858,"threshold_uncertainty_score":0.003920257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0202941193330707,"score_gpt":0.2410626369133607,"score_spread":0.22076851758029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}