{"id":"W4317888223","doi":"10.1002/1878-0261.13382","title":"Preclinical patient‐derived modeling of castration‐resistant prostate cancer facilitates individualized assessment of homologous recombination repair deficient disease","year":2023,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Deutscher Akademischer Austausch Dienst Kairo; Bundesministerium für Bildung und Forschung; Deutscher Akademischer Austauschdienst","keywords":"Olaparib; Prostate cancer; Homologous recombination; LNCaP; Cisplatin; Medicine; Cancer research; RAD51; PARP inhibitor; Ex vivo; Oncology; Internal medicine; Cancer; In vivo; Biology; Poly ADP ribose polymerase; Chemotherapy; Gene; Genetics; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004527733,0.0001386606,0.0004323886,0.0002368133,0.00005748531,0.000005032262,0.00007313568,0.0001051842,0.00005445862],"category_scores_gemma":[0.0002384407,0.0001157017,0.0001806611,0.0003903103,0.0001688699,0.00003727641,0.00009126751,0.000161595,0.000003188296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003074042,"about_ca_system_score_gemma":0.00122447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001447018,"about_ca_topic_score_gemma":0.00002088723,"domain_scores_codex":[0.9980027,0.0002902619,0.0006232641,0.000347478,0.000442192,0.0002940868],"domain_scores_gemma":[0.9988244,0.000131176,0.0002000828,0.0002729912,0.0004214212,0.0001499802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.01084799,0.005996812,0.08926456,0.003038051,0.001944438,0.002663696,0.007905482,0.05304632,0.7845113,0.001233401,0.000722123,0.03882578],"study_design_scores_gemma":[0.03941679,0.02764574,0.3332988,0.001511871,0.002307442,0.00004092755,0.005292276,0.4134904,0.1677777,0.006555662,0.001539555,0.001122796],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954782,0.001079497,0.00021399,0.001248894,0.0001346558,0.001193368,0.0001956681,0.00007649349,0.0003792527],"genre_scores_gemma":[0.9967738,0.0005330028,0.001642768,0.00005402207,0.000007024911,0.0004049904,0.0004312886,0.00001825184,0.0001348627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6167337,"threshold_uncertainty_score":0.471818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0597663359927444,"score_gpt":0.4158618493712263,"score_spread":0.3560955133784819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}