{"id":"W4317888223","doi":"10.1002/1878-0261.13382","title":"Preclinical patient‐derived modeling of castration‐resistant prostate cancer facilitates individualized assessment of homologous recombination repair deficient disease","year":2023,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Deutscher Akademischer Austausch Dienst Kairo; Bundesministerium für Bildung und Forschung; Deutscher Akademischer Austauschdienst","keywords":"Olaparib; Prostate cancer; Homologous recombination; LNCaP; Cisplatin; Medicine; Cancer research; RAD51; PARP inhibitor; Ex vivo; Oncology; Internal medicine; Cancer; In vivo; Biology; Poly ADP ribose polymerase; Chemotherapy; Gene; Genetics; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004167562,0.0006511546,0.000447254,0.000399606,0.0001900458,0.0006375135,0.0005865068,0.000466207,0.002571432],"category_scores_gemma":[0.0002192204,0.0002320886,0.0004321923,0.0002649985,0.0002678751,0.0002491258,0.0003320837,0.001293579,0.0006186423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005135892,"about_ca_system_score_gemma":0.0005804844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001606725,"about_ca_topic_score_gemma":0.002257211,"domain_scores_codex":[0.9997863,0.0000652268,0.00001374615,0.00004235452,0.00006410688,0.00002827739],"domain_scores_gemma":[0.9998055,0.00003558227,0.00004271445,0.00004469163,0.00002081385,0.00005075782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004376681,0.0006738484,0.002804444,0.0001529716,0.00004424257,0.0002451538,0.00007763458,0.005004754,0.9833392,0.000926073,0.0006515246,0.005642502],"study_design_scores_gemma":[0.0001347599,0.005977173,0.01205927,0.00003418148,0.0001645639,0.00239011,0.0001318611,0.02324775,0.9379345,0.0004854312,0.01739835,0.00004212396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.94568,0.002237655,0.04207604,0.0003592222,0.00009200567,0.0005619141,0.003781307,0.0005366539,0.004675284],"genre_scores_gemma":[0.9848104,0.001010274,0.009783045,0.00008824616,0.000008709053,0.0002526532,0.00231136,0.00006170306,0.001673584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002571432,"threshold_uncertainty_score":0.008602321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0597663359927444,"score_gpt":0.4158618493712263,"score_spread":0.3560955133784819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}