{"id":"W4317915794","doi":"10.1093/brain/awac459","title":"Blood–brain barrier opening of the default mode network in Alzheimer’s disease with magnetic resonance-guided focused ultrasound","year":2023,"lang":"en","type":"article","venue":"Brain","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Toronto Rehabilitation Institute; University of Toronto; Sunnybrook Health Science Centre","funders":"Harquail Centre for Neuromodulation; Canadian Institutes of Health Research; European Research Council; National Institutes of Health; Vetenskapsrådet; University College London; Sunnybrook Foundation; National Institute of Biomedical Imaging and Bioengineering; Weston Brain Institute; Focused Ultrasound Foundation; Alzheimer's Drug Discovery Foundation","keywords":"Medicine; Blood–brain barrier; Magnetic resonance imaging; Transcranial Doppler; Default mode network; Dementia; Precuneus; Neurodegeneration; Cognitive decline; Neuroscience; Neuroimaging; Cerebral amyloid angiopathy; Alzheimer's disease; Pathology; Psychology; Disease; Internal medicine; Functional magnetic resonance imaging; Radiology; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009234014,0.0003449171,0.0005914239,0.0001748688,0.0001941385,0.0002546818,0.0003045032,0.0004256268,0.001068509],"category_scores_gemma":[0.0006373898,0.0001497396,0.000346976,0.0001088921,0.0003391215,0.000304973,0.0002000034,0.0005211291,0.0001144636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002388642,"about_ca_system_score_gemma":0.0002979332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007604866,"about_ca_topic_score_gemma":0.001620466,"domain_scores_codex":[0.9997631,0.0001275933,0.00001663544,0.00003031002,0.00003132493,0.00003103649],"domain_scores_gemma":[0.9998536,0.00004158964,0.00003382504,0.00002061737,0.00001858784,0.00003166841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2144953,0.02706581,0.04731784,0.002034585,0.0009441448,0.00148399,0.0009922306,0.00147089,0.3354296,0.0006825291,0.002266385,0.3658167],"study_design_scores_gemma":[0.040453,0.5633141,0.301295,0.000414731,0.001498156,0.00445988,0.0006701553,0.007576504,0.06942032,0.002882876,0.007900845,0.0001145611],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957764,0.002203724,0.0009268939,0.00008568946,0.00002179742,0.0002127629,0.00004761724,0.00002238189,0.0007029076],"genre_scores_gemma":[0.9972889,0.0007704168,0.001141116,0.00007568602,0.00002060378,0.0002947186,0.00008469426,0.000002028198,0.0003217673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001068509,"threshold_uncertainty_score":0.004883468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0160889134439388,"score_gpt":0.2358131075976892,"score_spread":0.2197241941537504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}