{"id":"W4317915794","doi":"10.1093/brain/awac459","title":"Blood–brain barrier opening of the default mode network in Alzheimer’s disease with magnetic resonance-guided focused ultrasound","year":2023,"lang":"en","type":"article","venue":"Brain","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Toronto Rehabilitation Institute; University of Toronto; Sunnybrook Health Science Centre","funders":"Harquail Centre for Neuromodulation; Canadian Institutes of Health Research; European Research Council; National Institutes of Health; Vetenskapsrådet; University College London; Sunnybrook Foundation; National Institute of Biomedical Imaging and Bioengineering; Weston Brain Institute; Focused Ultrasound Foundation; Alzheimer's Drug Discovery Foundation","keywords":"Medicine; Blood–brain barrier; Magnetic resonance imaging; Transcranial Doppler; Default mode network; Dementia; Precuneus; Neurodegeneration; Cognitive decline; Neuroscience; Neuroimaging; Cerebral amyloid angiopathy; Alzheimer's disease; Pathology; Psychology; Disease; Internal medicine; Functional magnetic resonance imaging; Radiology; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001894733,0.0001652403,0.000180546,0.00005994091,0.00009555225,0.00002992074,0.0003143223,0.0000572745,0.0000624459],"category_scores_gemma":[0.0001222436,0.0001269653,0.00006100962,0.0009001013,0.00008102081,0.00006963183,0.0000345622,0.0001604825,0.000022612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001527109,"about_ca_system_score_gemma":0.00005683914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008204096,"about_ca_topic_score_gemma":0.0004158916,"domain_scores_codex":[0.9989369,0.00005590408,0.0002507097,0.0002127284,0.000188793,0.0003549879],"domain_scores_gemma":[0.9989128,0.0004734955,0.00003204691,0.0004605615,0.00002128108,0.00009979415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.0001123018,0.0001387812,0.1163828,0.0001177875,0.0002132585,0.00005032554,0.003713744,0.6986784,0.0721158,0.006735709,0.08441167,0.01732946],"study_design_scores_gemma":[0.00538391,0.0001239271,0.7406911,0.0007230315,0.0004224279,0.00004250752,0.000430103,0.1037101,0.004787629,0.008425718,0.1337604,0.001499151],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923159,0.002827903,0.0002581498,0.001259902,0.00008298817,0.000686409,0.00009087124,0.0002830096,0.002194884],"genre_scores_gemma":[0.9980424,0.00004316592,0.0006779997,0.0002932829,0.00009034591,0.0001984695,0.00002362923,0.00006469806,0.0005660066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6243083,"threshold_uncertainty_score":0.5177494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0160889134439388,"score_gpt":0.2358131075976892,"score_spread":0.2197241941537504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}