{"id":"W4317930664","doi":"10.1177/0271678x231152001","title":"Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease","year":2023,"lang":"en","type":"article","venue":"Journal of Cerebral Blood Flow & Metabolism","topic":"Advanced Neuroimaging Techniques and Applications","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hotchkiss Brain Institute; Université Laval; University of Calgary; Baycrest Hospital; Health Sciences Centre; McGill University; Montreal Heart Institute; University of British Columbia; Western University; University of Toronto; Université de Sherbrooke; McMaster University; Montreal Neurological Institute and Hospital; Lawson Health Research Institute; Jewish General Hospital; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; Esperion Therapeutics; Amarin Corporation; Biogen; National Institutes of Health; Canada Research Chairs; AstraZeneca; Eli Lilly and Company; Pfizer; Novo Nordisk; Eisai; U.S. Department of Defense; Sanofi; National Institute on Aging; Alzheimer's Association","keywords":"White matter; Dementia; Fractional anisotropy; Free water; Diffusion MRI; Positron emission tomography; Neuroscience; Hyperintensity; Alzheimer's disease; Psychology; Cognitive decline; Medicine; Pathology; Magnetic resonance imaging; Internal medicine; Disease; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008510801,0.0006067149,0.0005786341,0.0008579771,0.0004634336,0.0006051899,0.0003125225,0.0006852202,0.0005704269],"category_scores_gemma":[0.002486332,0.0002848619,0.0003200791,0.0006699053,0.0002798215,0.0004088692,0.0004722353,0.0004240775,0.0001438667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002156778,"about_ca_system_score_gemma":0.0002167004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002830238,"about_ca_topic_score_gemma":0.002868138,"domain_scores_codex":[0.9997115,0.00007428621,0.00004399319,0.00008928205,0.0000494013,0.00003146769],"domain_scores_gemma":[0.9995043,0.0001318171,0.0001774645,0.00005616627,0.00005935152,0.00007094064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007940639,0.00009734675,0.9941759,0.00002587082,0.0001694618,0.0002189022,0.0001638298,0.0001475433,0.001038538,0.00001831633,0.00003878033,0.003111411],"study_design_scores_gemma":[0.00001918884,0.0002791423,0.9979247,0.000006093837,0.00009954379,0.0005641442,0.0001244397,0.0005622812,0.0002214368,0.00008811743,0.0001062989,0.000004578617],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994575,0.0002625268,0.0001087737,0.000009727384,0.000002271194,0.000004178867,0.00005218612,0.000002172459,0.0001006938],"genre_scores_gemma":[0.9996203,0.0000823494,0.0001026089,0.000008630765,0.000005410521,0.000005202012,0.0001059508,9.794989e-7,0.00006866718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002830238,"threshold_uncertainty_score":0.005627573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02307282829565896,"score_gpt":0.2654199776694309,"score_spread":0.2423471493737719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}