{"id":"W4317932856","doi":"10.20944/preprints202301.0388.v1","title":"Significance of Conserved Regions in Coronavirus Spike Protein for Developing a Novel Vaccine against SARS-Cov-2 Infection","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Manitoba","funders":"Canadian Institutes of Health Research; Mitacs; Research Manitoba","keywords":"Coronavirus; Immunogenicity; Virology; Biology; Protein subunit; Spike Protein; Pandemic; Immune system; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Epitope; Vaccination; Spike (software development); Coronavirus disease 2019 (COVID-19); Computational biology; Antibody; Genetics; Gene; Medicine; Infectious disease (medical specialty); Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001734045,0.0005308138,0.001167044,0.0007945707,0.00009879067,0.00002256338,0.0005301579,0.0006411517,0.000005946947],"category_scores_gemma":[0.002562528,0.0005661736,0.0004026527,0.0007958319,0.0001471901,0.00009585713,0.001284741,0.001342389,0.0001868536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008264328,"about_ca_system_score_gemma":0.002192243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005908628,"about_ca_topic_score_gemma":0.002514481,"domain_scores_codex":[0.9958172,0.00014722,0.001278035,0.001439882,0.000608475,0.0007091882],"domain_scores_gemma":[0.996808,0.0003327152,0.0006048541,0.001484358,0.0007175907,0.00005247129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008421334,0.0003121894,0.3687286,0.002313476,0.0001722475,0.00003371294,0.0002650309,0.0000192582,0.6265952,0.0002868552,0.00003124697,0.0004000431],"study_design_scores_gemma":[0.002896013,0.00008316216,0.2728318,0.002426331,0.00006016266,0.000008602799,0.00004272976,0.0005533209,0.7119738,0.001272344,0.007454729,0.0003969643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846042,0.00008671272,0.005546864,0.001142715,0.0003669238,0.007247231,0.00007061868,0.0003064988,0.0006282602],"genre_scores_gemma":[0.9905071,0.00004830888,0.001302619,0.003388507,0.0001800832,0.00420089,0.00007032239,0.0001397216,0.0001624471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09589686,"threshold_uncertainty_score":0.999679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3904047174262947,"score_gpt":0.4537658748833099,"score_spread":0.0633611574570152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}