{"id":"W4317932994","doi":"10.3390/antiox12020239","title":"Klotho, Oxidative Stress, and Mitochondrial Damage in Kidney Disease","year":2023,"lang":"en","type":"review","venue":"Antioxidants","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Instituto de Salud Carlos III; CMG Reservoir Simulation Foundation; Fundación Canaria Instituto de Investigación Sanitaria de Canarias; Fundación Canaria de Investigación y Salud","keywords":"Oxidative stress; Klotho; Premature aging; Mitochondrion; Biology; Cell biology; Parkin; TFEB; Senescence; Transcription factor; Cancer research; Endocrinology; Internal medicine; Kidney; Medicine; Disease; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002614666,0.0007420424,0.0009972255,0.001797636,0.0002903438,0.0007884477,0.000480572,0.000766772,0.00297931],"category_scores_gemma":[0.0002889947,0.0001872183,0.0003203068,0.001745607,0.0003183642,0.0008264112,0.0005479032,0.001377305,0.001230825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004218445,"about_ca_system_score_gemma":0.0007946899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001099507,"about_ca_topic_score_gemma":0.002409003,"domain_scores_codex":[0.9998989,0.00001497034,0.00001638949,0.00001600964,0.0000430017,0.00001071622],"domain_scores_gemma":[0.9999039,0.00003677672,0.00001793495,0.000002613727,0.00002515149,0.0000136455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001016299,0.00008967506,0.0002077148,0.01919449,0.0001245421,0.0003367114,0.00007773352,0.0002922842,0.002547237,0.00343984,0.0289977,0.9445904],"study_design_scores_gemma":[0.00002327259,0.0001133518,0.001501923,0.003263945,0.0001439455,0.00201879,0.00008339043,0.00008952258,0.0004828614,0.002575034,0.9896857,0.00001825333],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008994441,0.9990219,0.00005155959,0.0001332742,0.0001206034,0.000002291193,0.000008687448,0.00000419981,0.0005676473],"genre_scores_gemma":[0.0006244854,0.998492,0.00009272168,0.0001124487,0.0001142442,0.000003679692,0.00001987696,7.714546e-7,0.0005397278],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00297931,"threshold_uncertainty_score":0.009966791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05228039082294385,"score_gpt":0.3654494964793973,"score_spread":0.3131691056564535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}