{"id":"W4317932994","doi":"10.3390/antiox12020239","title":"Klotho, Oxidative Stress, and Mitochondrial Damage in Kidney Disease","year":2023,"lang":"en","type":"review","venue":"Antioxidants","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Instituto de Salud Carlos III; CMG Reservoir Simulation Foundation; Fundación Canaria Instituto de Investigación Sanitaria de Canarias; Fundación Canaria de Investigación y Salud","keywords":"Oxidative stress; Klotho; Premature aging; Mitochondrion; Biology; Cell biology; Parkin; TFEB; Senescence; Transcription factor; Cancer research; Endocrinology; Internal medicine; Kidney; Medicine; Disease; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00006437086,0.0004677558,0.001504918,0.0003476539,0.0000603151,0.00003864115,0.0001162752,0.0002080641,0.00003128019],"category_scores_gemma":[0.0003120945,0.0003662503,0.0002619181,0.0004985051,0.00009997098,0.00009963293,0.0001121312,0.0002994322,0.000408595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006573719,"about_ca_system_score_gemma":0.000550023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009197007,"about_ca_topic_score_gemma":0.00006092667,"domain_scores_codex":[0.998111,0.0001184929,0.0004878452,0.0006429419,0.0002567598,0.0003829508],"domain_scores_gemma":[0.9987534,0.00009559354,0.0001899595,0.0004291679,0.00002947103,0.0005024116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001311485,0.008260071,0.07176243,0.1238477,0.006233247,0.03219965,0.0007867414,7.326195e-7,0.00005951144,0.001220342,0.155888,0.59843],"study_design_scores_gemma":[0.007313563,0.0002403818,0.02481529,0.05805409,0.003626325,0.00003580686,0.0000636076,0.00001329062,0.000005755096,0.0003034205,0.9045794,0.0009490705],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001733814,0.9946881,0.000002448727,0.00004587556,0.0002734302,0.001435474,0.0009330184,0.00007386744,0.0008139584],"genre_scores_gemma":[0.0001105713,0.9949699,0.00007439787,0.00007328596,0.0001670032,0.0001563033,0.001013925,0.00008792218,0.003346708],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7486914,"threshold_uncertainty_score":0.9998789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05228039082294385,"score_gpt":0.3654494964793973,"score_spread":0.3131691056564535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}