{"id":"W4317933043","doi":"10.3390/cancers15030711","title":"Long-Term Non-Cancer Risks in People with BRCA Mutations following Risk-Reducing Bilateral Salpingo-Oophorectomy and the Role of Hormone Replacement Therapy: A Review","year":2023,"lang":"en","type":"review","venue":"Cancers","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"University of British Columbia","keywords":"Medicine; Oophorectomy; Hormone replacement therapy (female-to-male); Hormone replacement; Cancer; Oncology; BRCA mutation; Gynecology; Hormone; Bioinformatics; Ovarian cancer; Internal medicine; Surgery; Hysterectomy; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006828542,0.0006078412,0.001527793,0.002145337,0.0002188309,0.0008113578,0.0006874006,0.000928902,0.003427991],"category_scores_gemma":[0.002268644,0.000243613,0.001162822,0.00195915,0.0002647859,0.0007177712,0.0004665218,0.000986463,0.0005671338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004903685,"about_ca_system_score_gemma":0.001419418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001911975,"about_ca_topic_score_gemma":0.003678091,"domain_scores_codex":[0.9996907,0.00007345746,0.00007448777,0.00004738091,0.00009576822,0.00001824362],"domain_scores_gemma":[0.9989192,0.0007951498,0.0001367336,0.00001122167,0.0001134511,0.00002418357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001287168,0.00005996865,0.0005245002,0.1028797,0.0004826267,0.0001706518,0.00009909483,0.0002484961,0.0004006839,0.001058691,0.01804311,0.8759037],"study_design_scores_gemma":[0.00006662487,0.0002954278,0.005602416,0.1100187,0.002642596,0.003111404,0.0002344605,0.0001538385,0.000424087,0.002053295,0.8753484,0.00004870147],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007496613,0.9994804,0.00002320883,0.0001279408,0.00006148107,0.000002867692,0.0000214759,0.000001856155,0.0002058992],"genre_scores_gemma":[0.0003503073,0.9994062,0.00004501412,0.00006903932,0.00003626236,0.00000338126,0.00001802191,4.415643e-7,0.00007143455],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003427991,"threshold_uncertainty_score":0.01146775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02786438085932371,"score_gpt":0.3444439902154702,"score_spread":0.3165796093561465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}