{"id":"W4317933186","doi":"10.3390/cells12030403","title":"Calnexin, More Than Just a Molecular Chaperone","year":2023,"lang":"en","type":"review","venue":"Cells","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Multiple Sclerosis Society; Children's Health Research Institute; Women and Children's Health Research Institute; Multiple Sclerosis Society of Canada","keywords":"Calnexin; Calreticulin; Chaperone (clinical); Endoplasmic reticulum; Cytosol; Cell biology; Protein folding; Transport protein; Biology; Membrane protein; Biochemistry; Membrane; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003078149,0.0006010777,0.0007882463,0.001300055,0.0002298742,0.001043449,0.0005891877,0.0007747746,0.003150873],"category_scores_gemma":[0.0004238743,0.000162022,0.0002142952,0.001713087,0.0003743862,0.00123789,0.0005354867,0.001410485,0.002820184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000547353,"about_ca_system_score_gemma":0.0009531302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008185749,"about_ca_topic_score_gemma":0.001396482,"domain_scores_codex":[0.9999056,0.00001173083,0.00001203751,0.00002150873,0.00003836959,0.00001071502],"domain_scores_gemma":[0.9998257,0.00005502511,0.00002459172,0.000007396564,0.00005592916,0.00003145358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004534126,0.00003924423,0.0002007216,0.007711786,0.00006258496,0.0001726231,0.00004870673,0.0001910847,0.002452104,0.004373541,0.05330346,0.9313988],"study_design_scores_gemma":[0.000003301866,0.00001901224,0.0002932193,0.0006176495,0.00002051553,0.0004639952,0.00001397691,0.000017981,0.0001946918,0.0008078503,0.9975431,0.000004598277],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001197087,0.9973119,0.0001237368,0.0004559233,0.000329532,0.000002336609,0.00002191923,0.00001012234,0.001624727],"genre_scores_gemma":[0.0008324282,0.997021,0.0001378401,0.0002577829,0.000257286,0.00000323491,0.00005532611,0.000002103661,0.001432881],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003150873,"threshold_uncertainty_score":0.01054072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03906696336215485,"score_gpt":0.3362896100532488,"score_spread":0.2972226466910939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}