{"id":"W4317933186","doi":"10.3390/cells12030403","title":"Calnexin, More Than Just a Molecular Chaperone","year":2023,"lang":"en","type":"review","venue":"Cells","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Multiple Sclerosis Society; Children's Health Research Institute; Women and Children's Health Research Institute; Multiple Sclerosis Society of Canada","keywords":"Calnexin; Calreticulin; Chaperone (clinical); Endoplasmic reticulum; Cytosol; Cell biology; Protein folding; Transport protein; Biology; Membrane protein; Biochemistry; Membrane; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008089039,0.000467875,0.000783655,0.00007786298,0.0000576848,0.00004014814,0.0004213546,0.0004563559,0.00004780779],"category_scores_gemma":[0.00004664081,0.0003922542,0.0006643085,0.0001658632,0.0001069232,0.000001351737,0.000286557,0.000191156,0.0005253099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001980256,"about_ca_system_score_gemma":0.0002160062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001483089,"about_ca_topic_score_gemma":0.000003345068,"domain_scores_codex":[0.9982269,0.00008246145,0.0003786927,0.0006982788,0.0001925881,0.0004210763],"domain_scores_gemma":[0.9987178,0.0000177662,0.0001739492,0.000796099,0.00004273866,0.0002516141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008376881,0.0007100154,0.0000136787,0.09308983,0.00277065,0.002556068,0.0001278639,0.00007783945,0.01615807,0.001167354,0.09077832,0.7924665],"study_design_scores_gemma":[0.000178077,0.00005689002,8.074154e-7,0.001616043,0.0004837231,0.00001736433,0.00002474249,0.000003561085,0.002263848,0.00001139081,0.9948671,0.0004764026],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004143461,0.9969155,0.00006744763,0.00001586083,0.0003601052,0.0004968301,0.0002899171,0.00004294312,0.001397048],"genre_scores_gemma":[0.0001047579,0.9936072,0.00006575808,0.00009986116,0.0003275748,0.0001627031,0.001180833,0.000138152,0.004313137],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9040889,"threshold_uncertainty_score":0.999853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03906696336215485,"score_gpt":0.3362896100532488,"score_spread":0.2972226466910939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}