{"id":"W4317951846","doi":"10.1038/s41586-022-05546-8","title":"Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies","year":2023,"lang":"en","type":"review","venue":"Nature","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":362,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; University of Alberta; McMaster University; Population Health Research Institute","funders":"National Heart, Lung, and Blood Institute; Biotechnology and Biological Sciences Research Council; National Institute of Allergy and Infectious Diseases; Medical Research Council; Horizon 2020 Framework Programme; Bijzonder Onderzoeksfonds UGent; Directorate for Biological Sciences; National Institutes of Health; U.S. Department of Health and Human Services; Canada Research Chairs; Deutsche Forschungsgemeinschaft; KU Leuven; National Institute of Nursing Research; National Institute for Health and Care Research; Vlaamse regering; Eunice Kennedy Shriver National Institute of Child Health and Human Development; NIHR Cambridge Biomedical Research Centre; European Commission; Broad Institute; Wellcome Trust; National Cancer Institute; Rural and Environment Science and Analytical Services Division; Science Foundation Ireland","keywords":"Microbiome; Human Microbiome Project; Biology; Metagenomics; Fetus; Microbial ecology; Human microbiome; Physiology; Ecology; Evolutionary biology; Computational biology; Pregnancy; Bioinformatics; Genetics; Bacteria; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0003838979,0.0004302308,0.0009858466,0.0001109459,0.0001647448,0.00003093969,0.0005363725,0.00275212,0.000006431527],"category_scores_gemma":[0.0001350795,0.00027635,0.000516781,0.0003540965,0.0002556258,0.000002456978,0.0003011013,0.001535926,0.00004371395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004841583,"about_ca_system_score_gemma":0.0004330085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001385312,"about_ca_topic_score_gemma":0.00007445276,"domain_scores_codex":[0.9982685,0.0001774083,0.0005620688,0.0005125264,0.0001058907,0.000373534],"domain_scores_gemma":[0.9987488,0.00006396694,0.0004355254,0.0004939463,0.0002075205,0.0000502614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007038847,0.0002408436,0.00001613485,0.1374837,0.004940203,0.00005287872,0.0003508737,0.000003927611,0.5311185,0.0003779845,0.2202125,0.1051321],"study_design_scores_gemma":[0.0001664974,0.00008288478,0.00001045435,0.006578762,0.0003208128,0.00009511923,0.00006260664,1.188418e-7,0.002684704,0.00001280157,0.9896507,0.0003345767],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001401959,0.9964175,0.000002012851,0.0001531009,0.000969373,0.0005701548,0.0004214936,0.0000240924,0.0000403168],"genre_scores_gemma":[0.0004149637,0.9956592,0.0001177976,0.0001592331,0.0007105411,0.00002433485,0.001048266,0.0000735279,0.00179209],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7694381,"threshold_uncertainty_score":0.9999689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03566020813606298,"score_gpt":0.3761009759199368,"score_spread":0.3404407677838738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}