{"id":"W4317951846","doi":"10.1038/s41586-022-05546-8","title":"Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies","year":2023,"lang":"en","type":"review","venue":"Nature","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":362,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; University of Alberta; McMaster University; Population Health Research Institute","funders":"National Heart, Lung, and Blood Institute; Biotechnology and Biological Sciences Research Council; National Institute of Allergy and Infectious Diseases; Medical Research Council; Horizon 2020 Framework Programme; Bijzonder Onderzoeksfonds UGent; Directorate for Biological Sciences; National Institutes of Health; U.S. Department of Health and Human Services; Canada Research Chairs; Deutsche Forschungsgemeinschaft; KU Leuven; National Institute of Nursing Research; National Institute for Health and Care Research; Vlaamse regering; Eunice Kennedy Shriver National Institute of Child Health and Human Development; NIHR Cambridge Biomedical Research Centre; European Commission; Broad Institute; Wellcome Trust; National Cancer Institute; Rural and Environment Science and Analytical Services Division; Science Foundation Ireland","keywords":"Microbiome; Human Microbiome Project; Biology; Metagenomics; Fetus; Microbial ecology; Human microbiome; Physiology; Ecology; Evolutionary biology; Computational biology; Pregnancy; Bioinformatics; Genetics; Bacteria; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.00309415,0.0009452556,0.001724674,0.001660813,0.0003651532,0.001936834,0.001125555,0.002442089,0.002279119],"category_scores_gemma":[0.00389885,0.0002868771,0.0005091303,0.001467346,0.001854371,0.002301672,0.00132735,0.003934594,0.001648922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001084039,"about_ca_system_score_gemma":0.001527314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001879051,"about_ca_topic_score_gemma":0.004176768,"domain_scores_codex":[0.9995311,0.0001421989,0.00004104227,0.00007758341,0.0001713124,0.00003670083],"domain_scores_gemma":[0.9964348,0.002628727,0.000149439,0.0001016557,0.0005089409,0.0001764407],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008700673,0.00003164948,0.000335512,0.006084885,0.00007877596,0.0002112797,0.00005641979,0.00024573,0.001606326,0.01458911,0.0507023,0.925971],"study_design_scores_gemma":[0.00001387014,0.00004942949,0.0006984291,0.003645938,0.00006434224,0.0008122037,0.0000845025,0.00009474019,0.000607389,0.01203693,0.9818632,0.00002913238],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005130611,0.9971365,0.0003455985,0.001303716,0.0004884258,0.000001619038,0.00001350067,0.000005855383,0.000653413],"genre_scores_gemma":[0.0006452183,0.9957368,0.0005833722,0.001357311,0.00105436,0.000006455146,0.00002163522,0.000005222006,0.0005896352],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9969059,"threshold_uncertainty_score":0.01636362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03566020813606298,"score_gpt":0.3761009759199368,"score_spread":0.3404407677838738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}