{"id":"W4317989663","doi":"10.1021/acs.molpharmaceut.2c00821","title":"The Chemistry of Creating Chemically Programmed Antibodies (cPAbs): Site-Specific Bioconjugation of Small Molecules","year":2023,"lang":"en","type":"review","venue":"Molecular Pharmaceutics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Small molecule; Chemistry; Bioconjugation; Conjugate; Pharmacophore; Monoclonal antibody; Antibody; Immunoglobulin Fab Fragments; Fragment crystallizable region; Combinatorial chemistry; Biochemistry; Biology; Receptor; Immunology; Complementarity determining region","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004763065,0.0007921141,0.0006321899,0.001260939,0.0002080217,0.0007306343,0.0007117707,0.0008550081,0.001677516],"category_scores_gemma":[0.0003918301,0.0003772772,0.0003973716,0.001177531,0.0006110086,0.001047705,0.0005389102,0.002114247,0.001628723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005806509,"about_ca_system_score_gemma":0.0006287405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005195797,"about_ca_topic_score_gemma":0.0005409992,"domain_scores_codex":[0.999689,0.00004434586,0.0000198932,0.00005296865,0.0001591859,0.0000345706],"domain_scores_gemma":[0.9998736,0.00005520504,0.00002423419,0.000006569896,0.00002963147,0.00001072861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007697527,0.0001684938,0.0001665673,0.01996621,0.0001037378,0.0003957904,0.0001531411,0.001477123,0.06771205,0.03789284,0.01839506,0.853492],"study_design_scores_gemma":[0.0000123209,0.0001532284,0.0002912404,0.0007607635,0.00003786098,0.001138394,0.00002638408,0.0002188171,0.02563229,0.002304232,0.9693993,0.00002515259],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001464842,0.9832056,0.005581019,0.0003491483,0.0004844748,0.00003909593,0.00003860623,0.0000582034,0.008778961],"genre_scores_gemma":[0.007522612,0.9845563,0.002796432,0.0003889593,0.0001638343,0.00007068158,0.00006276689,0.00001107203,0.004427399],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001677516,"threshold_uncertainty_score":0.005611837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1248265038789701,"score_gpt":0.4153411740811631,"score_spread":0.290514670202193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}