{"id":"W4317989663","doi":"10.1021/acs.molpharmaceut.2c00821","title":"The Chemistry of Creating Chemically Programmed Antibodies (cPAbs): Site-Specific Bioconjugation of Small Molecules","year":2023,"lang":"en","type":"review","venue":"Molecular Pharmaceutics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Small molecule; Chemistry; Bioconjugation; Conjugate; Pharmacophore; Monoclonal antibody; Antibody; Immunoglobulin Fab Fragments; Fragment crystallizable region; Combinatorial chemistry; Biochemistry; Biology; Receptor; Immunology; Complementarity determining region","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005708567,0.000481566,0.001508872,0.0001224422,0.0001252644,0.00003749902,0.0004547043,0.0003188706,0.00003461192],"category_scores_gemma":[0.0002925999,0.0003271747,0.0008729942,0.000633936,0.0005741807,0.00001292328,0.0003320259,0.0007703626,0.00003012077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007950837,"about_ca_system_score_gemma":0.0003686564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002264435,"about_ca_topic_score_gemma":0.00000120768,"domain_scores_codex":[0.9969029,0.0001519982,0.001206817,0.00044511,0.0007508858,0.0005422367],"domain_scores_gemma":[0.9975588,0.0005567984,0.0006745915,0.0005526852,0.0004523607,0.0002047352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001993756,0.0002967633,0.00007011135,0.1011671,0.001548565,0.0002612633,0.0001415403,0.000004997751,0.1334547,0.0002545189,0.0002909732,0.7623102],"study_design_scores_gemma":[0.000475877,0.00008814155,0.000006379587,0.009233881,0.001124586,0.00007894752,0.00004865411,0.0003278665,0.1132252,0.00003514502,0.8750364,0.0003188455],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003908905,0.992434,0.00007980483,0.0001378158,0.00007236945,0.001384336,0.0001492558,0.00006173031,0.001771787],"genre_scores_gemma":[0.0001940529,0.9962398,0.001338179,0.00002441175,0.0001435027,0.00009913459,0.0005844042,0.0001127785,0.001263679],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8747455,"threshold_uncertainty_score":0.999918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1248265038789701,"score_gpt":0.4153411740811631,"score_spread":0.290514670202193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}