{"id":"W4318019176","doi":"10.1021/acs.jproteome.2c00620","title":"CaspSites: A Database and Web Application for Experimentally Observed Human Caspase Substrates Using N-Terminomics","year":2023,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Machine Learning in Bioinformatics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Caspase; Cleavage (geology); World Wide Web; Web site; Computer science; Database; Apoptosis; Information retrieval; Biology; The Internet; Biochemistry; Programmed cell death","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001851408,0.00009005895,0.0001286975,0.0001921748,0.0002332787,0.00007024988,0.0002157678,0.0000825438,0.000003444627],"category_scores_gemma":[0.0002714388,0.00008079551,0.00005295018,0.0001659103,0.0001073256,0.00001710213,0.0001709928,0.0002259048,0.000002928287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000409509,"about_ca_system_score_gemma":0.0001757782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000299329,"about_ca_topic_score_gemma":0.0000223966,"domain_scores_codex":[0.998944,0.00008890735,0.00033553,0.0001347404,0.0002508472,0.000245971],"domain_scores_gemma":[0.9991427,0.00004653511,0.0001898424,0.0002104216,0.0003014679,0.0001090279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009667708,0.00002925538,0.002596808,0.0001479175,0.00002696301,0.00001057413,0.0000817036,0.0000833262,0.9963716,0.00005703398,0.0002674669,0.0002306225],"study_design_scores_gemma":[0.002164089,0.001584425,0.00241809,0.0001376449,0.00002417847,0.0003926639,0.001237928,0.05193315,0.9358808,0.0002773828,0.003668275,0.0002813698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979876,0.0001625327,0.001085146,0.00009334508,0.00002332217,0.0005783733,0.00002753847,0.000005445683,0.00003668838],"genre_scores_gemma":[0.9881356,0.00006103819,0.01128337,0.00001485861,0.0002407535,0.00004559724,0.00009571538,0.00002202771,0.0001010337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06049085,"threshold_uncertainty_score":0.3294745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1883632673709802,"score_gpt":0.4569847632528405,"score_spread":0.2686214958818603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}