{"id":"W4318033671","doi":"10.1101/2023.01.25.525520","title":"Genomic targets of HOP2 are enriched for features found at recombination hotspots","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Biology; Genetics; Homologous recombination; Chromatin immunoprecipitation; Chromatin; Histone; Genome; DNA; Gene; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004242732,0.0002873917,0.0002201273,0.0003881016,0.0002376971,0.0003684396,0.000112139,0.0002562873,0.004861469],"category_scores_gemma":[0.00009923427,0.0001955803,0.0001808394,0.0002485756,0.0001448555,0.0001176823,0.0002434454,0.0002664182,0.0009579838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001487006,"about_ca_system_score_gemma":0.0001101159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006176817,"about_ca_topic_score_gemma":0.0009081725,"domain_scores_codex":[0.9999194,0.000003182516,0.000002284559,0.00003578887,0.0000163872,0.0000230379],"domain_scores_gemma":[0.9999241,0.00001558794,0.00001528362,0.000008571341,0.000008266075,0.00002832577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001492743,0.000008509639,0.00207468,0.00004959349,0.00001347076,0.0001899013,0.00001689596,0.00007187795,0.995839,0.00007849498,0.000190612,0.001317826],"study_design_scores_gemma":[0.00003006662,0.00007995911,0.2890663,0.00001220997,0.00004475557,0.00136403,0.0001775951,0.001276881,0.7014595,0.0003313859,0.006138813,0.0000184546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903333,0.0010862,0.002416709,0.00007711354,0.00002243961,0.000008421001,0.00343868,0.0002063183,0.002410889],"genre_scores_gemma":[0.9857727,0.0002817604,0.001574531,0.0000797898,0.00001216011,0.00001757298,0.006144285,0.00007742466,0.006039813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004861469,"threshold_uncertainty_score":0.01626325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01568186968536738,"score_gpt":0.2332556229455278,"score_spread":0.2175737532601605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}